LEADER 05610nam 2200625 450 001 9910813756103321 005 20230803195630.0 010 $a1-908230-74-6 035 $a(CKB)2670000000547262 035 $a(EBL)1899231 035 $a(SSID)ssj0001216236 035 $a(PQKBManifestationID)11704113 035 $a(PQKBTitleCode)TC0001216236 035 $a(PQKBWorkID)11196838 035 $a(PQKB)11278570 035 $a(MiAaPQ)EBC1899231 035 $a(MiAaPQ)EBC5897878 035 $a(Au-PeEL)EBL5897878 035 $a(OCoLC)876882413 035 $a(EXLCZ)992670000000547262 100 $a20191016d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPhage therapy $ecurrent research and applications /$fedited by Jan Borysowski, Department of Clinical Immunology, The Medical University of Warsaw, Warsaw, Poland, Ryszard Mie?dzybrodzki and Andrzej Go?rski, Department of Clinical Immunology, The Medical University of Warsaw, Warsaw, and Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroc?aw, Poland 210 1$aNorfolk, England :$cCaister Academic Press,$d[2014] 210 4$dİ2014 215 $a1 online resource (402 p.) 300 $aDescription based upon print version of record. 311 $a1-908230-40-1 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Current books of interest; Foreword; Introduction; Part I: Characteristics of Phages as Antibacterial Agents; 1: General Characteristics of Bacteriophages; Introduction; Discovery; Basic phage techniques (Carlson, 2005); Habitats and ecology; Phage life; Host range; Classification; Genomics; Practical aspects of phage research; Electron microscopy for rapid diagnosis (Ackermann and Heldal, 2009; Ackermann, 2009); Outlook; 2: The First Step to Bacteriophage Therapy: How to Choose the Correct Phage; Introduction: therapeutic phages - what requirements should they meet? 327 $aEnvironmental sources of therapeutic phagesA brief overview of phage isolation methods; The selection of phages that infect encapsulated bacterial cells; Preliminary grouping of phage isolates; Pre-selection of potential therapeutic phages; Perspectives for the prediction of phage therapeutic efficacy; Purification of phage lysates; Bacteriophage stability; Host range determination; Bacterial strains for therapeutic phage propagation; Bacterial phage resistance - is it a concern?; Concluding remarks; 3: Bacteriophages as Drugs: The Pharmacology of Phage Therapy; Introduction; Pharmacology 327 $aPrimary pharmacodynamicsSecondary pharmacodynamics; Accumulation rates; Concentrations; Absorption and distribution; Spectrum of activity; Development issues; Conclusion; 4: Fighting Bacteriophage Infection: Mechanisms of Bacterial Resistance; Introduction; Preventing phage adsorption; Preventing phage DNA entry; Degradation of phage nucleic acids; Abortive infection systems; Conclusion; 5: Non-bactericidal Effects of Phages in Mammals; Introduction; Phages and cell adhesion; Overview of main aspects of phage antigenicity; The influence of phages on cytokine production 327 $aPhage influence on phagocytosis and oxidative burstEngineered phages as vaccines; Phages and pathogenic viruses of mammals; Remarks on bacterial remains in phage preparations; Conclusions; Part II: Applications of Phages and Phage-derived Enzymes as Antibacterials; 6: Overview of Therapeutic Applications of Bacteriophages; The use of lytic phages; The therapeutic use of phage lysins; Genetically engineered phages; Phages as delivery vectors; 7: Considerations for Using Bacteriophages in Plant Pathosystems; Introduction; Impediments in using phage therapy in plant pathology 327 $aFuture considerations for improving phage efficacyPhages as part of integrated management strategy; Conclusions; 8: Bacteriophage Therapy in Animal Production; Introduction; Bacteriophage therapy in poultry production; Bacteriophage therapy in swine production; Bacteriophage therapy in beef, dairy and cattle production; Bacteriophage therapy in aquaculture; General discussion; 9: The Use of Phages as Biocontrol Agents in Foods; Introduction; Bacteriophages as biocontrol agents; The use of phages as biocontrol agents against specific food-borne bacteria 327 $aMain factors that determine the efficacy of phages as biocontrol agents 330 $aThe emergence of bacteria resistant to multiple antibiotics has become a serious threat to public health and is considered one of the greatest challenges for contemporary medicine. Phage therapy - the use of bacteriophages as anti-bacterial agents - may offer an alternative treatment for bacterial infections. Phages have many potential applications in human medicine, as well as in dentistry, veterinary science, agriculture, and food protection. Written by internationally recognized experts from leading centers involved in phage research and phage therapy, this book provides comprehensive cover 606 $aBacteriophages$xTherapeutic use 606 $aAntibacterial agents 615 0$aBacteriophages$xTherapeutic use. 615 0$aAntibacterial agents. 676 $a579.26 702 $aBorysowski$b Jan 702 $aMie?dzybrodzki$b Ryszard 702 $aGo?rski$b Andrzej 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910813756103321 996 $aPhage therapy$94097814 997 $aUNINA