LEADER 05494nam 2200733 450 001 9910813701203321 005 20220408095710.0 010 $a1-118-74414-4 010 $a1-118-74418-7 010 $a1-118-74416-0 035 $a(CKB)2550000001138462 035 $a(EBL)1501637 035 $a(OCoLC)862049689 035 $a(SSID)ssj0001040594 035 $a(PQKBManifestationID)11601172 035 $a(PQKBTitleCode)TC0001040594 035 $a(PQKBWorkID)11001753 035 $a(PQKB)11610567 035 $a(MiAaPQ)EBC1501637 035 $a(Au-PeEL)EBL1501637 035 $a(CaPaEBR)ebr10788056 035 $a(CaONFJC)MIL538163 035 $a(PPN)204414474 035 $a(EXLCZ)992550000001138462 100 $a20131109d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFood allergy $eadverse reactions to foods and food additives /$fedited by Dean D. Metcalfe [and three others] 205 $aFifth edition. 210 1$aChichester, England :$cWiley-Blackwell,$d2014. 210 4$d©2014 215 $a1 online resource (626 p.) 300 $aDescription based upon print version of record. 311 $a0-470-67255-2 311 $a1-306-06912-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFood Allergy; Contents; List of Contributors; Preface to the Fifth Edition; Abbreviations; 1 Adverse Reactions to Food Antigens: Basic Science; 1 The Mucosal Immune System; Introduction; Mucosal immunity is associated with suppression: the phenomena of controlled inflammation and oral tolerance; Controlled/physiologic inflammation; Oral tolerance; The nature of antibody responses in the gut-associated lymphoid tissue; The anatomy of the gut-associated lymphoid tissue: antigen trafficking patterns; References; 2 The Immunological Basis of IgE-Mediated Reactions; Introduction 327 $aRoute of sensitizationAllergen uptake in the intestine; T-cell response in IgE-mediated allergy; B-cell response in IgE-mediated allergy; Allergen-specific IgG and IgA; Genes and environment; Innate immune recognition of allergens; Allergic inflammation; IgE receptors; Mast cells; Basophils; Eosinophils; Conclusion; References; 3 The Immunological Basis of Non-IgE-Mediated Reactions; Introduction; Development of food allergy; Gut anatomy; Defense mechanisms; Oral tolerance; Antigen transport; Antigen processing and presentation; T cells; Eosinophils 327 $aFood protein-induced enterocolitis and proctocolitisCeliac disease; Allergic eosinophilic esophagitis and gastroenteritis; Conclusions; Acknowledgment; References; 4 Food Allergens-Molecular and Immunological Characteristics; Introduction; Food allergen protein families; Food allergens of animal origin (Table 4.2); Tropomyosins; Parvalbumins; Caseins; Minor families; Food allergens of plant origin (Table 4.3); The prolamin superfamily; The cupin superfamily; The Bet v 1 family; Minor families; Allergen databases; What does this mean?; Acknowledgment; References 327 $a5 Biotechnology and Genetic EngineeringIntroduction; Plant biotechnology; Roundup Ready soybeans: a case study in food safety assessment; Development and benefits of Roundup Ready soybeans; Safety assessment of Roundup Ready soybeans; General assessment strategy for food allergy; Analyzing the sources of introduced genes; Amino acid sequence comparisons to known allergens; Protein stability; in vitroimmunoassays of allergenicity; in vivoassays of allergenicity; Changes in endogenous allergens (substantial equivalence); Allergy assessment summary: Roundup Ready soybeans 327 $aTrends in the science of risk assessmentAnimal models for predicting allergenicity; Refinements of in vitropepsin digestion assay; Value of measuring allergen expression levels as part of the allergy risk assessment of biotech crops; Removing allergens from foods; International consensus: a common strategy; Conclusion and future considerations; References; 6 Food Allergen Thresholds of Reactivity*; Definition of threshold; Thresholds for sensitization versus elicitation; Clinical determination of individual threshold doses; Clinical correlates of thresholds of reactivity 327 $aMEDs for specific foods 330 $aEdited by world-renowned experts in the field, Food Allergy covers pediatric and adult adverse reactions to foods and food additives in one comprehensive volume. Designed to be a practical, readable reference for use in the hospital or private practice setting, the text is organized into five sections covering basic and clinical perspectives of adverse reactions to food antigens; adverse reactions to food additives; and contemporary topics. Two chapters in the fifth edition are devoted to food biotechnology and genetic engineering. 606 $aAl·lèrgia alimentària$2thub 606 $aAdditius alimentaris$2thub 606 $aFood allergy 606 $aFood additives$xHealth aspects 608 $aLlibres electrònics$2thub 615 7$aAl·lèrgia alimentària 615 7$aAdditius alimentaris 615 0$aFood allergy. 615 0$aFood additives$xHealth aspects. 676 $a616.97/5 701 $aMetcalfe$b Dean D$0919994 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910813701203321 996 $aFood allergy$94005498 997 $aUNINA