LEADER 05333nam 2200661Ia 450 001 9910813605303321 005 20200520144314.0 010 $a1-281-11215-1 010 $a9786611112158 010 $a0-08-055622-1 035 $a(CKB)1000000000405578 035 $a(EBL)328580 035 $a(OCoLC)437197020 035 $a(SSID)ssj0000111956 035 $a(PQKBManifestationID)11819473 035 $a(PQKBTitleCode)TC0000111956 035 $a(PQKBWorkID)10085723 035 $a(PQKB)10271580 035 $a(Au-PeEL)EBL328580 035 $a(CaPaEBR)ebr10204425 035 $a(CaONFJC)MIL111215 035 $z(PPN)182574865 035 $a(MiAaPQ)EBC328580 035 $a(PPN)170257398 035 $a(EXLCZ)991000000000405578 100 $a20070622d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiological inorganic chemistry $ean introduction /$fRobert R. Crichton with the collaboration of Fre deric Lallemand, Ionna S.M. Psalti and Roberta J Ward 205 $a1st ed. 210 $aAmsterdam ;$aOxford $cElsevier$d2008 215 $a1 online resource (383 p.) 300 $aDescription based upon print version of record. 311 $a0-444-52740-0 320 $aIncludes bibliographical references and index. 327 $aFront cover; Biological Inorganic Chemistry An Introduction; Copyright page; Preface; Contents; Chapter 1. An Overview of Metals in Biology; Introduction; Why do we Need Anything Other Than C, H, N and O (Together with Some P And S)?; What are the Essential Metal Ions?; References; Chapter 2. Basic Coordination Chemistry for Biologists; Introduction; Hard and Soft Ligands; Coordination Geometry; Crystal Field Theory and Ligand Field Theory; References; Chapter 3. Biological Ligands for Metal Ions; Introduction; Protein Amino Acid Residues (and Derivatives) as Ligands 327 $aAn Example of a Non-Protein Ligand: Carbonate and PhosphateEngineering Metal Insertion Into Organic Cofactors; Chelatase: Terminal Step in Tetrapyrrole Metallation; Iron-Sulfur Cluster Containing Proteins; Iron-Sulfur Cluster Formation; Copper Insertion into Superoxide Dismutase; More Complex Cofactors: MoCo, FeMoCo, P-Clusters, H-Clusters and CuZ; Siderophores; References; Chapter 4. Structural and Molecular Biology for Chemists; Introduction; The Structural Building Blocks of Proteins; Primary, Secondary, Tertiary and Quaternary Structures of Proteins 327 $aSecondary and Tertiary Structures of Nucleic AcidsReferences; Chapter 5. An Overview of Intermediary Metabolism and Bioenergetics; Introduction; Redox Reactions in Metabolism; The Central Role of ATP in Metabolism; The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism; An Overview of Intermediary Metabolism: Catabolism; Selected Case Studies: Glycolysis and the Tricarboxylic Acid Cycle; An Overview of Intermediary Metabolism: Anabolism; Bioenergetics: Generation of Phosphoryl Transfer Potential at the Expense of Proton Gradients; References 327 $aChapter 6. Methods to Study Metals in Biological SystemsIntroduction; Magnetic Properties; Electron Paramagnetic Resonance (EPR) Spectroscopy; Mo?ssbauer Spectroscopy; NMR Spectroscopy; Electronic and Vibrational Spectroscopies; Circular Dichroism and Magnetic Circular Dichroism; Resonance Raman Spectroscopy; Extended X-Ray Absorption Fine Structure; X-Ray Diffraction; References; Chapter 7. Metal Assimilation Pathways; Introduction; Metal Assimilation in Bacteria; Metal Assimilation in Plants and Fungi; Metal Assimilation in Mammals; References 327 $aChapter 8. Transport, Storage and Homeostasis of Metal IonsIntroduction; Metal Storage and Homeostasis in Bacteria; Metal Transport, Storage and Homeostasis in Plants and Fungi; Metal Transport, Storage and Homeostasis in Mammals; References; Chapter 9. Sodium and Potassium-Channels and Pumps; Introduction: -Transport Across Membranes; Sodium Versuspotassium; Sodium Channels; References; Chapter 10. Magnesium-Phosphate Metabolism and Photoreceptors; Introduction; Magnesium-Dependent Enzymes; Phosphoryl Group Transfer: Kinases; Phosphoryl Group Transfer: Phosphatases 327 $aStabilization of Enolate Anions: The Enolase Super Family 330 $aThe importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of th 606 $aBioinorganic chemistry 606 $aChemistry, Inorganic 615 0$aBioinorganic chemistry. 615 0$aChemistry, Inorganic. 676 $a572.51 700 $aCrichton$b Robert R$0520760 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910813605303321 996 $aBiological inorganic chemistry$92094024 997 $aUNINA