LEADER 02756nam 2200541 a 450 001 9910813278503321 005 20240516061059.0 010 $a1-283-17621-1 010 $a9786613176219 010 $a1-118-08440-3 010 $a1-118-08441-1 010 $a1-118-08439-X 035 $a(CKB)2550000000041143 035 $a(EBL)693195 035 $a(OCoLC)729718072 035 $a(MiAaPQ)EBC693195 035 $a(MiAaPQ)EBC4031741 035 $a(Au-PeEL)EBL693195 035 $a(CaPaEBR)ebr10483221 035 $a(CaONFJC)MIL317621 035 $a(EXLCZ)992550000000041143 100 $a20110408d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aKinetics of enzyme action $eessential principles for drug hunters /$fRoss L. Stein 205 $a1st ed. 210 $aHoboken, N.J. $cWiley$dc2011 215 $a1 online resource (302 p.) 311 $a0-470-41411-1 320 $aIncludes bibliographical references and index. 327 $aKinetics of single-substrate enzymatic reactions -- Kinetics of single-substrate enzymatic reactions : special topics -- Enzyme inhibition : the phenomenon and mechanistic analysis -- Kinetic mechanism of inhibition of one-substrate enzymatic reactions -- Tight-binding, slow-binding, and irreversible inhibitors -- Kinetics of two-substrate enzymatic reactions -- Kinetic mechanism of inhibition of two-substrate enzymatic reactions -- Allosteric modulation of enzyme-catalyzed reactions -- Kinetics-based probes of enzyme mechanisms. 330 $a"Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery"--Provided by publisher. 606 $aEnzymes$xPharmacokinetics 606 $aEnzyme inhibitors$xPharmacokinetics 615 0$aEnzymes$xPharmacokinetics. 615 0$aEnzyme inhibitors$xPharmacokinetics. 676 $a572/.7 700 $aStein$b Ross L$01646594 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910813278503321 996 $aKinetics of enzyme action$93993679 997 $aUNINA