LEADER 04608oam 2200469 450 001 9910813264803321 005 20190911100030.0 010 $a0-12-800073-2 035 $a(OCoLC)865658341 035 $a(MiFhGG)GVRL6ZYJ 035 $a(EXLCZ)992670000000488533 100 $a20140501d2013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aCatecholamine research in the 21st century $eabstracts and graphical abstracts, 10th International Catecholamine Symposium, 2012 /$fedited by Lee E. Eiden 210 1$aLondon :$cAcademic Press,$d2013. 215 $a1 online resource (xxi, 253 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a0-12-800044-9 320 $aIncludes bibliographical references. 327 $aFront Cover; Catecholamine Research in the 21st Century; Copyright Page; Contents; Preface; THEME A: CATECHOLAMINE BIOSYNTHESIS AND STORAGE; 1. Genetic Manipulation of Catecholamine Signaling in the Mouse; 2. AADC Deficiency: Occurring in Humans; Modeled in Rodents; Treated in Patients; 3. Tyrosine Hydrolylase and Dopamine Beta-Hydroxylase: Role of Common Genetic Variation in Adrenergic Responses to Stress and ...; 4. Pharmacokinetic and Pharmacodynamic Properties of Etamicastat, a New DBH Inhibitor: Comparison to Nepicastat 327 $a5. Estradiol-Mediated Regulation of Gene Expression of Catecholamine Biosynthetic Enzymes: The Role of Membrane-Initiated Sign...6. Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines; 7. Unique Regulation of TH Gene Expression in Midbrain Dopamine Neurons; 8. Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme; 9. The Peripheral Interaction of Tyrosine Hydroxylase and 14-3-3? with Negatively Charged Phospholipidic Membranes; References 327 $a10. Dynamic Regulation of Tyrosine Hydroxylase Gene Expression by Key Fate-Determining Transcription Factors during Dopaminergi...11. Analysis of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson's Disease; 12. Non-dopaminergic Neurons Partly Expressing Dopaminergic Phenotype: Functional Significance and Regulation; 13. Developing Brain as an Endocrine Organ: Catecholamines Secretion and Endocrine Action; 14. Brainstem DOPAergic System; 15. Imaging Norepinephrine Transporters in Humans; Translational Research with PET 327 $a16. Imaging the Vesicular Monoamine Transporter (VMAT2) in Neurodegenerative Diseases17. GTP Cyclohydrolase Regulation: Implications for Brain Development and Function; 18. Neonatal Diagnosis of Menkes Disease by a Pattern of Plasma Catechols; 19. Catecholamine Metabolites Affected by the Copper-Dependent Enzyme Dopamine-Beta-Hydroxylase Provide Sensitive Blood and Csf...; 20. Are the Enzymes of the Catecholamine Biosynthetic Pathway Locally Synthesized in the Axon? 327 $a21. Effects of Missense Mutations in Tyrosine Hydroxylase (TH) Found in Patients with Neurological Disorders Attributed to TH D...22. Tetrahydrobiopterin Deficiency Impairs Postnatal Increase of TH Protein via Insufficient Dopamine Biosynthesis; 23. Selective Ablation of Dopamine Beta-Hydroxylase Neurons (Subpopulation of TH Neurons) in the Brain: New Insights into Brain...; 24. Neural Circuit Mechanism for Learning Dependent on Dopamine Transmission: Roles of Striatal Direct and Indirect Pathways in... 327 $a25. Regulation of Tyrosine Hydroxylase by Ser19-Phosphorylation-Dependent Binding to 14-3-3? 330 $a Through the use of extended graphical abstracts and some traditional text-only abstracts this collection provides, a record of and roadmap to, the research presented at The Tenth International Catecholamine Symposium (XICS) held in September of 2012. Organized around ten general themes, each is introduced by a short overview identifying interesting research programs, results and potential areas of growth. The collection is a roadmap to key research and future opportunities for new catecholamine research programs and will be of interest to neuroscientists and clinical neurologists interested 606 $aCatecholamines$vCongresses 615 0$aCatecholamines 676 $a617.378 702 $aEiden$b Lee E. 712 12$aInternational Catecholamine Symposium 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910813264803321 996 $aCatecholamine research in the 21st century$93973355 997 $aUNINA