LEADER 01030nam0-22003371i-450- 001 990003741670403321 005 20040317142108.0 010 $a0-8039-0846-6 035 $a000374167 035 $aFED01000374167 035 $a(Aleph)000374167FED01 035 $a000374167 100 $a20030910d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aCreating Reality$eHow TV News Distorts Events$fDavid L. Altheide 210 $aBeverly Hills$cSAGE$dİ1974 215 $a221 p.$ctav.$d22 cm 300 $aContiene riferimenti bibl. 300 $aOriginariamente pubblicato come volume 33 nella collana "Sage library of social research" 610 0 $aTelegiornali$aStati Uniti 610 0 $aGiornalismo$aAspetti sociali 676 $a302.23 700 1$aAltheide,$bDavid L.$f<1945- >$027655 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003741670403321 952 $a302.23 ALT 1$b2408$fBFS 959 $aBFS 996 $aCreating Reality$929164 997 $aUNINA LEADER 04715nam 2200637 450 001 9910811820003321 005 20200520144314.0 010 $a1-78539-787-7 035 $a(CKB)2670000000612293 035 $a(EBL)2036170 035 $a(SSID)ssj0001535296 035 $a(PQKBManifestationID)11860435 035 $a(PQKBTitleCode)TC0001535296 035 $a(PQKBWorkID)11498915 035 $a(PQKB)11018673 035 $a(MiAaPQ)EBC2036170 035 $a(Au-PeEL)EBL2036170 035 $a(CaPaEBR)ebr11049157 035 $a(CaONFJC)MIL776945 035 $a(OCoLC)909903386 035 $a(PPN)199373388 035 $a(EXLCZ)992670000000612293 100 $a20150509h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBasic principles of drug discovery and development /$fBenjamin E. Blass 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (591 p.) 300 $aDescription based upon print version of record. 311 $a0-12-411508-X 311 $a0-12-411525-X 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $aFront Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1 - Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2 - The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY 327 $aPAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3 - Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4 - In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN 327 $aBIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5 - Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS 327 $aEXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8 - Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9 - Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY 327 $aDELIVERY METHODS 330 $aBasic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicin 606 $aDrug development 606 $aDrugs$xDesign 615 0$aDrug development. 615 0$aDrugs$xDesign. 676 $a615.19 686 $a44.38$2bcl 700 $aBenjamin$b Blass$01624240 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910811820003321 996 $aBasic principles of drug discovery and development$93959129 997 $aUNINA