LEADER 01082nam--2200349---450- 001 990006098790203316 005 20151113115939.0 035 $a000609879 035 $aUSA01000609879 035 $a(ALEPH)000609879USA01 035 $a000609879 100 $a20151103d1961----km-y0itay50------ba 101 $aita$ctur 102 $aIT 105 $a||||||||001yy 200 1 $aUomini, topi e ancora uomini$fEgidio Meneghetti$gprefazione e traduzione di Franco De Poli$gdisegni di Giuseppe Motti 210 $aMilano$cAvanti$d1961$aRoma 215 $a229 p., [18] c. di tav.$d13 cm 225 2 $a<> Gallo$v67 300 $aTitolo della copertina: Uomini, animali e ancora uomini 410 0$a<> Gallo$v, 67 606 0 $aScienze$2BNCF 676 $a500.2 700 1$aMENEGHETTI,$bEgidio$0571113 801 0$aIT$bsalbc$gISBD 912 $a990006098790203316 951 $aXV.9.M. 1856$b3563 MAR$cXV.9.M.$d379640 959 $aBK 969 $aMAR 979 $aCHIARA$b90$c20151113$lUSA01$h1159 996 $aUomini, topi e ancora uomini$91383382 997 $aUNISA LEADER 11601nam 2200685Ia 450 001 9910811528003321 005 20200520144314.0 010 $a0-309-17512-7 010 $a1-280-19183-X 010 $a9786610191833 010 $a0-309-58989-4 010 $a0-585-14663-2 035 $a(CKB)110986584751910 035 $a(OCoLC)559401952 035 $a(CaPaEBR)ebrary10055625 035 $a(SSID)ssj0000249203 035 $a(PQKBManifestationID)11176642 035 $a(PQKBTitleCode)TC0000249203 035 $a(PQKBWorkID)10205934 035 $a(PQKB)10260240 035 $a(MiAaPQ)EBC3376408 035 $a(Au-PeEL)EBL3376408 035 $a(CaPaEBR)ebr10055625 035 $a(OCoLC)814270941 035 $a(EXLCZ)99110986584751910 100 $a19970225d1996 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSpacecraft maximum allowable concentrations for selected airborne contaminants$hVolume 3 /$fSubcommittee on Spacecraft Maximum Allowable Concentrations, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1996 215 $a1 online resource (362 p.) 300 $a"The project was supported by the National Aeronautics and Space Administration grant no. NAGW-2239"--T.p. verso. 311 $a0-309-05629-2 320 $aIncludes bibliographical references. 327 $aSpacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants -- Copyright -- Preface -- Contents -- SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SELECTED AIRBORNE CONTAMINANTS: Introduction -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING SMACS -- REVIEW OF SMAC REPORTS -- REFERENCES -- Appendix A GUIDELINES FOR DEVELOPING SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION... -- GUIDELINES FOR DEVELOPING SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION CONTAMINANTS ... -- ENVIRONMENTAL CONTROL AND LIFE-SUPPORT SYSTEM -- MODIFICATION OF CONTAMINANT TOXICITY BY ENVIRONMENTAL FACTORS -- SOURCES AND TYPES OF DATA FOR ESTABLISHMENT OF SMACS -- Chemical-Physical Characteristics of Toxicants -- In Vitro Toxicity Studies -- Animal Toxicity Studies -- Clinical and Epidemiological Observations -- Pharmacokinetics and Metabolism -- Biological Markers -- RISK ASSESSMENT (DEVELOPMENT OF EXPOSURE CRITERIA) -- ISSUES IN MAKING RECOMMENDATIONS FOR THE ESTABLISHMENT OF SMACS -- Appendix B REPORTS ON SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SELECTED AIRBORNE CONTAMINANTS -- B1 BROMOTRIFLUOROMETHANE (HALON 1301) -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Toxicokinetics -- Metabolism -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Human Exposures -- CNS Effects -- Cardiac Effects -- Irritation -- Animal Exposures -- CNS Effects -- Cardiac Effects -- Histopathology and Mortality -- Subchronic Exposures -- Developmental Toxicity -- Mutagenicity -- Carcinogenicity -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Studies Not Considered in Setting ACs -- Studies on ''Impure'' Halon 1301 -- Studies on Irritation -- Studies on Short-Term Exposures of Animals -- Studies Considered in Setting ACs -- Studies on CNS Effects in Humans. 327 $aStudies on Cardiovascular Effects in Humans -- Studies on Subchronic Exposures in Animals -- ACKNOWLEDGMENT -- REFERENCES -- B2 1-BUTANOL -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption -- Distribution -- Elimination -- Metabolism -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Irritation -- CNS Effects -- Light Adaptation -- Hepatotoxicity -- Lethality -- Subchronic and Chronic Exposures -- Inhalation Exposures -- Oral Exposures -- Epidemiological Studies in Workers -- Genotoxicity -- Reproductive Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Irritation and Inflammation of the Eyes -- CNS Effects -- Long-Term Systemic Injury -- Spaceflight Effects -- RECOMMENDATIONS -- REFERENCES -- B3 TERT-BUTANOL -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption -- Distribution -- Elimination -- Metabolism -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Subchronic Exposures -- Chronic Exposures -- Carcinogenicity -- Genotoxicity -- Reproductive Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- CNS Effects -- Renal Lesions and Tumors -- Urinary-Bladder Injury -- Thyroid Lesions and Tumors -- Spaceflight Effects -- RECOMMENDATIONS -- REFERENCES -- B4 DIACETONE ALCOHOL -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption -- Distribution -- Elimination -- Metabolism -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Subchronic and Chronic Exposures -- Carcinogenicity -- Genotoxicity -- Reproductive Toxicity -- Developmental Toxicity -- Interactions with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- CNS Depression. 327 $aIrritation of Eyes and Throat -- Potential Liver Injury -- RECOMMENDATIONS -- REFERENCES -- B5 DICHLOROACETYLENE -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption -- Distribution -- Elimination -- Metabolism -- TOXICITY SUMMARY -- Acute Exposures -- Short-Term Exposures -- Subchronic and Chronic Exposures -- Noncancer Toxicity -- Carcinogenicity -- Genotoxicity -- Biological Interactions -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Nephrotoxicity -- Hepatotoxicity -- Neurotoxicity -- Lethality -- Summary -- REFERENCES -- B6 1, 2-DICHLOROETHANE -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Toxicokinetics -- Metabolism -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Lethality -- Cause of Death and Internal Injuries -- Miscellaneous Symptoms -- CNS Depression -- Corneal Opacity -- Bacterial Respiratory Infection -- Subchronic and Chronic Exposures -- Miscellaneous Symptoms -- Gastroenterological and Hepatic Toxicity -- Carcinogenicity -- Genotoxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- CNS Effects -- Gastrointestinal Symptoms -- Liver Toxicity -- Impaired Host Defense -- Carcinogenesis -- Establishment of SMACs -- REFERENCES -- B7 ETHANOL -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption -- Distribution -- Excretion -- Metabolism -- Understanding of Ethanol Metabolism Before 1900 -- Understanding of Ethanol Metabolism by 1950 -- Present Understanding of Ethanol Metabolism -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Neurotoxicity -- Mucosal Irritation -- Flush Response -- Subchronic and Chronic Exposures -- Hepatotoxicity -- Carcinogenicity -- Mutagenicity and Genotoxicity -- Reproductive Toxicity. 327 $aDevelopmental Toxicity -- Interaction with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Neurotoxicity -- Mucosal and Eye Irritation -- Hepatotoxicity -- Flush Response -- RECOMMENDATIONS -- REFERENCES -- B8 ETHYLBENZENE -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- TOXICITY SUMMARY -- Acute and Short-Term Exposures -- Lethality -- Eye and Respiratory Irritation -- CNS Effects -- Subchronic Exposures -- Lethality -- NOAELs for All Measured Effects -- Respiratory Distress, CNS Effects -- Neurochemical Changes -- Chronic Exposures -- Sleepiness, Fatigue, Eye, and Respiratory Irritation and Headache -- Carcinogenicity -- Kidney and Liver Changes -- Testicular Toxicity -- Genotoxicity -- Reproductive and Developmental Toxicity -- Interactions with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Eye and Respiratory Irritation -- Testicular Toxicity -- Sleepiness and Headache -- Spaceflight Considerations -- RECOMMENDATIONS -- REFERENCES -- B9 ETHYLENE GLYCOL -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption -- Metabolism -- Excretion -- Toxicokinetics -- TOXICITY SUMMARY -- Acute or Short-Term Exposures -- Lethality -- CNS, Cardiopulmonary, and Renal Toxicity -- Metabolic Acidosis and Miscellaneous Signs and Symptoms -- Mucosal Irritation -- Subchronic and Chronic Exposures -- Mucosal Irritation and Eye Toxicity -- CNS Effects -- Renal Toxicity -- Potential Effect on the Liver -- Potential Hematological Effects -- Lethality -- Carcinogenesis -- Genotoxicity -- Reproductive Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Mucosal Irritation -- CNS Depression -- Renal Toxicity -- Establishment of SMAC Values -- RECOMMENDATIONS -- REFERENCES. 327 $aB10 GLUTARALDEHYDE -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- TOXICITY SUMMARY -- Background -- Acute Exposures -- Irritation and Depressed Weight Gain -- Respiratory Distress -- Hepatitis -- Lethality -- Genotoxicity -- Subchronic Exposures -- Lethality -- Irritation, Hematological Effects, and Decreased Organ Weights -- Contact Dermatitis -- Respiratory Difficulty, Rhinitis, Headache, Watering of the Eyes -- Reproductive and Developmental Toxicity -- Carcinogenicity -- Interactions with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Respiratory Difficulty, Rhinitis, Headache, Watering of the Eyes -- Lesions of the Respiratory Tract -- Hepatitis -- SPACEFLIGHT CONSIDERATIONS -- REFERENCES -- B11 TRICHLOROETHYLENE -- PHYSICAL AND CHEMICAL PROPERTIES -- OCCURRENCE AND USE -- TOXICOKINETICS AND METABOLISM -- Absorption and Distribution -- Elimination -- Metabolism -- TOXICITY SUMMARY -- Acute Exposures -- Short-Term and Subchronic Exposures -- Chronic Exposures -- Noncarcinogenicity -- Carcinogenicity -- Genotoxicity -- Reproductive and Developmental Effects -- Interactions with Other Chemicals -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- CNS Effects -- Cardiac Sensitization to Arrhythmia -- Hepatotoxicity and Nephrotoxicity -- Carcinogenesis -- Summary -- REFERENCES -- B12 XYLENE -- PHYSICAL AND CHEMICAL PROPERTIES -- TOXICOKINETICS AND METABOLISM -- TOXICITY SUMMARY -- Acute Exposures -- Subchronic Exposures -- Chronic Exposures -- Carcinogenicity and Genotoxicity -- Gastrointestinal Effects in Humans -- RATIONALE FOR ACCEPTABLE CONCENTRATIONS -- Lethality -- 1-h and 24-h ACs in Humans -- 1-h and 24-h ACs in Rats -- Throat Irritation -- 1-h and 24-h ACs -- 7-d 30-d, and 180-d ACs -- Eye Irritation -- Histopathological Changes -- Narcosis -- Reduced Cardiac Output. 327 $aSPACEFLIGHT CONSIDERATIONS. 606 $aSpace cabin atmospheres 606 $aSpace vehicles$xContamination 606 $aSpace vehicles$xAir pollution 606 $aSpace vehicles$xAir quality$xStandards 615 0$aSpace cabin atmospheres. 615 0$aSpace vehicles$xContamination. 615 0$aSpace vehicles$xAir pollution. 615 0$aSpace vehicles$xAir quality$xStandards. 676 $a629.47/7 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910811528003321 996 $aSpacecraft maximum allowable concentrations for selected airborne contaminants$93935404 997 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