LEADER 04459nam 2200697Ia 450 001 9910811409703321 005 20200520144314.0 010 $a0-309-17319-1 010 $a1-280-18599-6 010 $a9786610185993 010 $a0-309-59698-X 010 $a0-585-06800-3 035 $a(CKB)110986584752654 035 $a(OCoLC)70772784 035 $a(CaPaEBR)ebrary10056956 035 $a(SSID)ssj0000106767 035 $a(PQKBManifestationID)11128707 035 $a(PQKBTitleCode)TC0000106767 035 $a(PQKBWorkID)10110645 035 $a(PQKB)10667702 035 $a(MiAaPQ)EBC3376680 035 $a(Au-PeEL)EBL3376680 035 $a(CaPaEBR)ebr10056956 035 $a(CaONFJC)MIL18599 035 $a(OCoLC)923265549 035 $a(EXLCZ)99110986584752654 100 $a19990524d1999 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAssessment of future scientific needs for live variola virus /$fCommittee on the Assessment of Future Scientific Needs for Live Variola Virus, Board on Global Health, Institute of Medicine 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1999 215 $a1 online resource (126 pages) $cillustrations 225 1 $aThe compass series 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a0-309-06441-4 320 $aIncludes bibliographical references (p. 87-91). 327 $aAssessment of Future Scientific Needs for Live Variola Virus -- Copyright -- Preface -- Acknowledgments -- REVIEWERS -- Contents -- Executive Summary -- SCOPE -- SCIENTIFIC NEEDS FOR LIVE AND REPLICATION-DEFECTIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- Part I Introduction -- 1 Introduction -- BACKGROUND -- CONTEMPORARY CONTEXT -- SCOPE -- SCIENTIFIC NEEDS FOR VARIOLA VIRUS -- ORGANIZATION OF THIS REPORT -- Part II Smallpox and Its Control -- 2 Variola Virus and Other Orthopoxviruses -- GENERAL ATTRIBUTES OF ORTHOPOXVIRUSES -- POXVIRUS REPLICATION -- PROPERTIES OF SPECIFIC ORTHOPOXVIRUSES -- 3 Clinical Features of Smallpox -- ENTRY AND INFECTION -- DISSEMINATION -- THE RASH -- LESIONS OF THE MUCOUS MEMBRANES -- EFFECTS ON OTHER ORGANS -- IMMUNE RESPONSE -- IMMUNITY AGAINST SMALLPOX -- 4 Epidemiology -- CHARACTERISTICS OF HISTORICAL OUTBREAKS -- LIKELY CHARACTERISTICS OF FUTURE SMALLPOX OUTBREAKS -- CONTROL STRATEGIES -- 5 Variola Virus Stocks Following Eradication of Smallpox -- ESTABLISHMENT OF INTERNATIONAL REPOSITORIES -- DECISION BY THE WORLD HEALTH ASSEMBLY TO DESTROY VARIOLA VIRUS STOCKS -- U.S. RESEARCH ON SMALLPOX -- RESEARCH AT CDC AND USAMRIID -- Part III Scientific Needs for Variola Virus -- 6 Development of Antiviral Agents -- IN VITRO ASSAYS -- ANIMAL MODELS -- 7 Development of Vaccines -- CURRENT STATUS OF VACCINIA VACCINE PREPARATIONS -- EVALUATION OF VACCINIA VACCINE DERIVED FROM TISSUE CULTURE -- EVALUATION OF NOVEL VACCINES -- 8 Detection and Diagnosis -- ENVIRONMENTAL DETECTION -- DIAGNOSIS OF INFECTION -- ALTERNATIVES TO LIVE VIRUS -- 9 Bioinformatics -- VARIABILITY OF VARIOLA VIRUS -- POTENTIAL DEVELOPMENTS -- 10 Understanding of the Biology of Variola Virus -- VIRUS-CELL INTERACTIONS -- VIRUS-HOST INTERACTIONS -- 11 Research on the Expressed Protein Products of Variola -- SYNTHESIS OF VARIOLA PROTEINS. 327 $aPOTENTIAL UTILITY OF VARIOLA PROTEINS -- Part IV Findings -- 12 Summary and Conclusions -- THE BROADER CONTEXT -- SCIENTIFIC NEEDS FOR LIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- References -- Appendix A Glossary -- Appendix B Acronyms -- Appendix C Committee and Staff Biographies -- Staff. 410 0$aCompass series (Washington, D.C.) 517 3 $aLive variola virus 606 $aSmallpox$xResearch 606 $aSmallpox$xPrevention 606 $aSmallpox vaccine 606 $aVirology$xCultures and culture media 615 0$aSmallpox$xResearch. 615 0$aSmallpox$xPrevention. 615 0$aSmallpox vaccine. 615 0$aVirology$xCultures and culture media. 676 $a616.9/12 712 02$aInstitute of Medicine (U.S.).$bCommittee on the Assessment of Future Scientific Needs for Live Variola Virus. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910811409703321 996 $aAssessment of future scientific needs for live variola virus$94037708 997 $aUNINA