LEADER 03802nam 2200601Ia 450 001 9910811243903321 005 20230725015502.0 010 $a1-118-03517-8 010 $a1-282-68599-6 010 $a9786612685996 010 $a0-470-62732-8 010 $a0-470-62731-X 035 $a(CKB)2560000000011791 035 $a(EBL)540093 035 $a(OCoLC)654805678 035 $a(SSID)ssj0000437280 035 $a(PQKBManifestationID)11320508 035 $a(PQKBTitleCode)TC0000437280 035 $a(PQKBWorkID)10432506 035 $a(PQKB)10565344 035 $a(MiAaPQ)EBC540093 035 $a(Au-PeEL)EBL540093 035 $a(CaPaEBR)ebr10392949 035 $a(CaONFJC)MIL268599 035 $a(EXLCZ)992560000000011791 100 $a20091211d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGPCR molecular pharmacology and drug targeting$b[electronic resource] $eshifting paradigms and new directions /$fedited by Annette Gilchrist 210 $aHoboken, N.J. $cWiley$dc2010 215 $a1 online resource (544 p.) 300 $aIncludes index. 311 $a0-470-30778-1 327 $aGPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy 327 $aCHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery 327 $aCHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX 330 $aG protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference. 606 $aG proteins 606 $aDrug targeting 615 0$aG proteins. 615 0$aDrug targeting. 676 $a612/.015756 701 $aGilchrist$b Annette$0930108 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910811243903321 996 $aGPCR molecular pharmacology and drug targeting$94031697 997 $aUNINA