LEADER 04274nam 22006972 450 001 9910810983503321 005 20221206231500.0 010 $a1-107-13046-8 010 $a1-280-41821-4 010 $a9786610418213 010 $a1-139-16476-7 010 $a1-139-14710-2 010 $a0-511-18056-X 010 $a0-511-05706-7 010 $a0-511-30755-1 010 $a0-511-07185-X 035 $a(CKB)1000000000014478 035 $a(EBL)217666 035 $a(OCoLC)437068906 035 $a(SSID)ssj0000161749 035 $a(PQKBManifestationID)11159364 035 $a(PQKBTitleCode)TC0000161749 035 $a(PQKBWorkID)10219333 035 $a(PQKB)11208335 035 $a(UkCbUP)CR9781139164764 035 $a(MiAaPQ)EBC217666 035 $a(Au-PeEL)EBL217666 035 $a(CaPaEBR)ebr10069866 035 $a(CaONFJC)MIL41821 035 $a(PPN)261358847 035 $a(EXLCZ)991000000000014478 100 $a20111007d2003|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenomic Perl $efrom bioinformatics basics to working code /$fRex A. Dwyer$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2003. 215 $a1 online resource (xvii, 334 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-511-06339-3 311 $a0-521-80177-X 320 $aIncludes bibliographical references (p. 318-323) and index. 327 $aCover; Half-title; Title; Copyright; Dedication; Contents; Preface; Acknowledgments; CHAPTER ONE The Central Dogma; CHAPTER TWO RNA Secondary Structure; CHAPTER THREE Comparing DNA Sequences; CHAPTER FOUR Predicting Species: Statistical Models; CHAPTER FIVE Substitution Matrices for Amino Acids; CHAPTER SIX Sequence Databases; CHAPTER SEVEN Local Alignment and the BLAST Heuristic; CHAPTER EIGHT Statistics of BLAST Database Searches; CHAPTER NINE Multiple Sequence Alignment I; CHAPTER TEN Multiple Sequence Alignment II; CHAPTER ELEVEN Phylogeny Reconstruction 327 $aCHAPTER TWELVE Protein Motifs and PROSITECHAPTER THIRTEEN Fragment Assembly; CHAPTER FOURTEEN Coding Sequence Prediction with Dicodons; CHAPTER FIFTEEN Satellite Identification; CHAPTER SIXTEEN Restriction Mapping; CHAPTER SEVENTEEN Rearranging Genomes: Gates and Hurdles; APPENDIX A Drawing RNA Cloverleaves; APPENDIX B Space-Saving Strategies for Alignment; APPENDIX C A Data Structure for Disjoint Sets; APPENDIX D Suggestions for Further Reading; Bibliography; Index 330 $aThis introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD. 606 $aPerl (Computer program language) 606 $aMolecular biology$xData processing 606 $aBioinformatics 615 0$aPerl (Computer program language) 615 0$aMolecular biology$xData processing. 615 0$aBioinformatics. 676 $a572.80285 700 $aDwyer$b Rex A.$0632535 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910810983503321 996 $aGenomic perl$91201689 997 $aUNINA