LEADER 04692nam 2200685 a 450 001 9910810942003321 005 20240516083806.0 010 $a1-283-14368-2 010 $a9786613143686 010 $a981-4271-76-4 035 $a(CKB)3360000000001316 035 $a(EBL)731334 035 $a(OCoLC)741492841 035 $a(SSID)ssj0000525154 035 $a(PQKBManifestationID)12213200 035 $a(PQKBTitleCode)TC0000525154 035 $a(PQKBWorkID)10488395 035 $a(PQKB)11084242 035 $a(MiAaPQ)EBC731334 035 $a(WSP)00007269 035 $a(Au-PeEL)EBL731334 035 $a(CaPaEBR)ebr10480228 035 $a(CaONFJC)MIL314368 035 $a(EXLCZ)993360000000001316 100 $a20100618d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe quantal theory of immunity $ethe molecular basis of autoimmunity and leukemia /$fKendall A. Smith 205 $a1st ed. 210 $aSingapore ;$aHackensack, N.J. $cWorld Scientific$d2010 215 $a1 online resource (200 p.) 300 $aDescription based upon print version of record. 311 $a981-4271-75-6 320 $aIncludes bibliographical references and index. 327 $aAcknowledgements; Prologue; Contents; Chapter 1 Introduction - The Evolution of Our Understanding of the Immune System; Chapter 2 Molecular Immunology; Chapter 3 The Problem - Understanding How Molecules Direct the Behavior of Cells Comprising the Immune System; Chapter 4 The Quantal Theory of Immunity; Chapter 5 The Variability of Cell Cycle Progression and the Competence and Progression Phases of the Cell Cycle; Chapter 6 The Quantal Nature of IL-2-Promoted T Cell Cycle Progression 327 $aChapter 7 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - TheIL-2/Receptor InteractionChapter 8 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell CycleProgression - IL-2 and IL-2 Receptor Metabolism; Chapter 9 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 Receptor Signaling viathe Jak/Stat Pathway; Chapter 10 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 Receptor Signaling via Phospho 327 $aChapter 11 The T Cell Antigen Receptor Complex and the Quantal Regulation of the IL-2 and IL-2R GenesChapter 12 Digital Signaling via the T Cell Antigen Receptor Complex; Chapter 13 Negative Feedback Regulation of T Cell Antigen Receptor Complex Signaling - Attenuation of IL-2Gene Expression; Chapter 14 The Paradox of the IL-2 (-/-) Mouse; Chapter 15 The Scurfy Mouse; Chapter 16 Lymphopenia, Autoimmunity and the Regulatory T Cell (Treg); Chapter 17 Treg-mediated "Active Suppression" of T Cell Proliferation; Chapter 18 FOXP3, A Better ID-Tag for Tregs?; Chapter 19 Mice Versus Men 327 $aChapter 20 Active Versus Passive Suppression and IL-2 MetabolismChapter 21 FOXP3 Restricts But Does Not Suppress IL-2 Production; Chapter 22 Both the TCR and IL-2 Regulate FOXP3 Expression; Chapter 23 The Effects of FOXP3 Expression; Chapter 24 The Role of IL-2 in the Generation of Immune Responses In Vivo; Chapter 25 The Role of the IL-2r Chains in IL-2 Signaling, Consumption and Suppression of T Cell Proliferation; Chapter 26 T Cell Tissue-specific Autoimmunity; Chapter 27 Type 1 Diabetes Mellitus (T1DM), a Prototypic Genetic Autoimmune Disease with a Tie to IL-2 327 $aChapter 28 The Pathogenesis of Leukemia - Loss of Normal Quantal Growth ControlEpilogue; Index 330 $aThis book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a 606 $aImmune response 606 $aInterleukin-2 606 $aT cells 615 0$aImmune response. 615 0$aInterleukin-2. 615 0$aT cells. 676 $a616.079 676 $a616.97/8 676 $a616.978 700 $aSmith$b Kendall A$01718330 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910810942003321 996 $aThe quantal theory of immunity$94115185 997 $aUNINA