LEADER 03241nam 2200481 450 001 9910810803803321 005 20230316232504.0 010 $a0-309-47119-2 010 $a0-309-47117-6 035 $a(CKB)4100000004838156 035 $a(MiAaPQ)EBC5406370 035 $a(EXLCZ)994100000004838156 100 $a20180618d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvancing disease modeling in animal-based research in support of precision medicine $eproceedings of a workshop /$fErin Hammers Forstag and Lida Anestidou, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division of Earth and Life Studies, the National Academies of Sciences, Engineering, Medicine 210 1$aWashington, DC :$cThe National Academies Press,$d[2018] 210 4$dİ2018 215 $a1 online resource (xiii, 122 pages) $cillustrations 311 $a0-309-47116-8 327 $aIntroduction to precision medicine and animal models -- Existing precision medicine initiatives -- The promise and perils of animal models -- Reproducibility and predictivity -- In vitro alternatives to animal models -- Assessing safety and toxicology -- Patient perspectives -- Reflections on the workshop -- References. 330 $a"Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop"--Publisher's description. 606 $aAnimal models in research$vCongresses 606 $aPrecision medicine$vCongresses 615 0$aAnimal models in research 615 0$aPrecision medicine 676 $a616.0754 702 $aForstag$b Erin Hammers 702 $aAnestidou$b Lida 712 02$aRoundtable on Science and Welfare in Laboratory Animal Use. 712 02$aInstitute for Laboratory Animal Research. 712 02$aDivision of Earth and Life Studies. 712 02$aNational Academies of Sciences, Engineering, Medicine. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910810803803321 996 $aAdvancing disease modeling in animal-based research in support of precision medicine$94051300 997 $aUNINA