LEADER 05345nam 2200673Ia 450 001 9910810488803321 005 20221206103609.0 010 $a1-283-73425-7 010 $a0-12-382220-3 035 $a(CKB)2670000000274590 035 $a(EBL)1058161 035 $a(OCoLC)818819268 035 $a(SSID)ssj0000791439 035 $a(PQKBManifestationID)12387322 035 $a(PQKBTitleCode)TC0000791439 035 $a(PQKBWorkID)10758447 035 $a(PQKB)10323121 035 $a(Au-PeEL)EBL1058161 035 $a(CaPaEBR)ebr10621137 035 $a(CaONFJC)MIL404675 035 $z(PPN)182565238 035 $a(MiAaPQ)EBC1058161 035 $a(PPN)176533958 035 $a(EXLCZ)992670000000274590 100 $a20120813d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of proteolytic enzymes$hVolume 1 /$fedited by, Neil D. Rawlings, Guy Salvesen 205 $a3rd ed. 210 $aOxford $cAcademic$d2012 215 $a1 online resource (3987 p.) 300 $aPrevious ed.: London: Elsevier Academic, 2004. 311 $a0-12-382219-X 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases 327 $aClans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History 327 $aActivity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity 327 $aStructural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History 327 $aActivity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects 327 $aFurther Reading 330 $aThe third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also 606 $aProteolytic enzymes 606 $aCellular control mechanisms 615 0$aProteolytic enzymes. 615 0$aCellular control mechanisms. 676 $a572.76 676 $a572.76 701 $aRawlings$b Neil D$0729272 701 $aSalvesen$b G$01649985 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910810488803321 996 $aHandbook of proteolytic enzymes$93999093 997 $aUNINA