LEADER 05562nam 2200697 450 001 9910810323903321 005 20200520144314.0 010 $a1-908818-67-0 010 $a1-907568-45-X 035 $a(CKB)3710000000312799 035 $a(EBL)1887729 035 $a(SSID)ssj0001455004 035 $a(PQKBManifestationID)11801783 035 $a(PQKBTitleCode)TC0001455004 035 $a(PQKBWorkID)11500441 035 $a(PQKB)10586098 035 $a(Au-PeEL)EBL1887729 035 $a(CaPaEBR)ebr11000075 035 $a(CaONFJC)MIL679159 035 $a(OCoLC)898421820 035 $a(MiAaPQ)EBC1887729 035 $a(EXLCZ)993710000000312799 100 $a20150112h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aControlled drug delivery $ethe role of self-assembling multi-task excipients /$fedited by M. A. Mateescu, P. Ispas-Szabo, E. Assaad 210 1$aCambridge, [England] :$cWoodhead Publishing,$d2015. 210 4$dİ2015 215 $a1 online resource (269 p.) 225 1 $aWoodhead Publishing Series in Biomedicine ;$vNumber 74 300 $aDescription based upon print version of record. 311 $a1-322-47877-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Controlled Drug Delivery; Copyright Page; Contents; List of figures; List of tables; Biography for book; 1 The concept of self-assembling and the interactions involved; 1.1 The concept of self-assembling; 1.1.1 The concept of self-assembling by association/interaction processes; 1.2 The nature of forces and types of interactions involved in self-assembly of macromolecules; 1.3 Hydrogels and their role in drug conception and development; 1.3.1 Organogels and micelles for drug delivery; 1.4 Self-assembling phenomena in solid dosage forms 327 $a1.4.1 Hydrogen association and flexibility of chains1.4.2 Ionically stabilized excipients; 1.4.2.1 Two-speed self-assembled monolithic devices; 1.4.3 Hydrophobic stabilization of excipients and drug release mechanisms; 1.4.3.1 The concept of self-assembling by inclusion processes; 1.4.3.2 Inclusion complexes of starch with fatty bioactive agents; 1.4.3.3 Inclusion complexes and hydrophobic assembly of starch excipients; 1.5 Conclusions; References; 2 Starch and derivatives as pharmaceutical excipients; 2.1 General aspects; 2.2 Structural considerations 327 $a2.3 Self-assembling in physically modified starches2.3.1 Pregelatinized starch; 2.3.2 Multifunctional excipient: binder-filler and binder-disintegrant; 2.3.3 Extruded starch; 2.3.4 Soft starch capsules; 2.3.5 Hard capsules; 2.3.6 Starch films as functional coatings; 2.3.7 Starch microspheres and nanospheres in drug delivery; 2.3.8 Starch complexes; 2.3.9 Conclusions; 2.4 Chemically modified starches and their self-assembling; 2.4.1 Self-assembling in cross-linked starches; 2.4.2 Starch ethers; 2.4.3 Ionic starches and their self-assembling features; 2.4.3.1 CMS as pH-responsive excipient 327 $a2.4.3.2 Cationic starch2.4.4 Conclusions; References; 3 Chitosan and its derivatives as self-assembled systems for drug delivery; Abbreviations; 3.1 Introduction; 3.2 Unmodified chitosan-self-assembled thermogels; 3.2.1 Mechanism of chitosan thermogelation; 3.2.2 Chitosan thermogels; 3.3 Amphiphilic chitosan derivatives; 3.3.1 Alkylated chitosan; 3.3.2 Acylated chitosan; 3.3.2.1 Acylated chitosan; 3.3.2.2 Acylated chitosan oligosaccharides; 3.3.3 Cholesterol-modified chitosan; 3.3.4 Cholic and deoxycholic acid-modified chitosan; 3.3.5 5?-Cholanic acid-modified chitosan 327 $a3.3.6 Phthaloylchitosan and other hydrophobically modified chitosans3.3.7 Hydrophobic drug-grafted chitosan; 3.4 Amphiphilic/amphoteric chitosan derivatives; 3.4.1 Hydrophobically modified carboxylated chitosan; 3.4.1.1 Alkyl-modified carboxylated chitosan; 3.4.1.2 Acyl-modified carboxylated chitosan; 3.4.1.3 Cholesterol-modified carboxylated chitosan; 3.4.1.4 Deoxycholic acid-modified carboxylated chitosan; 3.4.2 Hydrophobically modified sulfated chitosan; 3.5 Conclusion; References; 4 Chitosan-based polyelectrolyte complexes as pharmaceutical excipients; Abbreviations 327 $a4.1 Introduction to chitosan-based polyelectrolyte complexes 330 $aIn complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this comprehensive book include: the concept of self-assembling; starch and derivatives as pharmaceutical excipients; and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Later chapters discuss polyelectrolyte complexes as excipient 410 0$aWoodhead Publishing series in biomedicine ;$vNumber 74. 606 $aDrug delivery systems 606 $aExcipients 606 $aSelf-organizing systems 615 0$aDrug delivery systems. 615 0$aExcipients. 615 0$aSelf-organizing systems. 676 $a615.6 702 $aMateescu$b M. A. 702 $aIspas-Szabo$b Pompilia 702 $aAssaad$b Elias 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910810323903321 996 $aControlled drug delivery$9473475 997 $aUNINA