LEADER 06664nam 2200613Ia 450 001 9910809637103321 005 20200520144314.0 010 $a1-61761-251-0 035 $a(CKB)2550000001041402 035 $a(EBL)3018588 035 $a(SSID)ssj0000853339 035 $a(PQKBManifestationID)12368450 035 $a(PQKBTitleCode)TC0000853339 035 $a(PQKBWorkID)10865669 035 $a(PQKB)10210447 035 $a(MiAaPQ)EBC3018588 035 $a(Au-PeEL)EBL3018588 035 $a(CaPaEBR)ebr10660449 035 $a(OCoLC)836871497 035 $a(EXLCZ)992550000001041402 100 $a20100625d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular aspects of infectious disease /$fMazen T. Saleh, editor 205 $a1st ed. 210 $aNew York $cNova Science Publishers$dc2011 215 $a1 online resource (214 p.) 225 0 $aImmunology and immune system disorders 225 0 $aNova biomedical 300 $aDescription based upon print version of record. 311 $a1-61728-690-7 320 $aIncludes bibliographical references and index. 327 $aIntro -- MOLECULAR ASPECTS OF INFECTIOUS DISEASE -- MOLECULAR ASPECTS OF INFECTIOUS DISEASE -- Library of Congress Cataloging-in-Publication Data -- Contents -- Chapter I Overview -- Epidemiology -- Host-Pathogen Interaction -- Emerging Infectious Diseases -- Chapter II Structure and Function of Bacterial and Fungal Cell Walls -- Bacterial Cell Walls -- Gram-Positive Cell Walls -- Mycobacterial Cell Walls -- Gram-Negative Cell Walls -- Fungal Cell Walls -- Conclusion -- References -- Chapter III Bacterial Cell Surface Structures Important in Pathogenesis -- Importance of the Bacterial Cell Surface -- Bacterial Capsules and Slime Layers -- S-Layers -- References -- Chapter IV An Introduction to Protein Secretion in Prokaryotes -- Type I Secretion System (T1ss) -- Architecture -- Mechanism of Transport -- Protein Folding -- Summary -- Type II Secretion System (T2ss) -- General Secretory Pathway (Gsp) -- Architecture -- Mechanism of Transport -- Protein Folding -- Twin Arginine Translocation (Tat) Pathway -- Architecture -- Mechanism of Transport -- Outer Membrane Transport -- Summary -- Type III Secretion System (T3ss) -- Architecture -- Mechanism of Transport -- Summary -- Type IV Secretion System (T4ss) -- Architecture -- Mechanism of Transport -- Summary -- Type V Secretion System (T5ss) -- Autotransporters (Va) -- Two-Partner Secretion (Vb) -- Oligomeric Coiled-Coil Adhesins (Vc) -- Summary -- Type VI Secretion System (T6ss) -- Architecture and Mechanism of Transport -- Summary -- Type VII Secretion System (T7ss) -- Architecture and Mechanism of Transport -- Summary -- Conclusion -- References -- Chapter V Viruses -- Basic Structure -- The Viral Lifecycle within Host Cells -- Survey of Medically Important Viruses -- Therapeutic Strategies -- References -- Chapter VI The Innate Immune System -- Abstract -- 1. General Description. 327 $a2. Nature of the Innate Immune System Repertoire -- 3. Mechanisms of Recognition by the Innate System - Receptor-Specific Responses -- I. Secreted PRR -- II. Cytoplasmic PRR -- III. Cell Surface Receptors -- Toll-Like Receptors -- 4. Cell Types and Processes Involved in the Innate Immune System -- I. Innate Barriers to Infection -- II. Innate Immune Cells -- II. Innate Immune Cells -- IV. Cytokine and Chemokine Production -- 5. Inflammatory Responses -- 6. Antigen Processing - Role of Innate Immunity in Stimulating Adaptive Immune Responses -- 7. Disorders of the Innate Immune System -- References -- Chapter VII Respiratory Infections -- Abstract -- Introduction -- Pulmonary Infections -- Streptococcus Pneumoniae -- Colonization of Upper Airways -- Invasion and Dissemination -- Immune Defense and Inflammation -- Immune Evasion -- PSEUDOMONAS AERUGINOSA -- Clinical Significance -- Pseudomonas Aeruginosa in CF -- Mechanisms of Microbial Pathogenesis -- Apoptosis of Host Cells Caused by Pseudomonas Aeruginosa -- Molecular Mechanisms of Inflammation Caused by Pseudomonas Aeruginosa Infection -- The Role of Airway Epithelial Cells in the Pathogenesis of Pseudomonas Aeruginosa Pulmonary Infections -- Immune Evasion -- Conclusion -- References -- Chapter VIII Prions -- Abstract -- Introduction -- Infectious but Proteinaceous Pathogens -- Isolation of Infectious Agents Composed of Proteins only -- Identification of Prp Gene -- Protein-only Hypothesis -- Isoforms of Prion Protein: PrPc and PrPsc -- PrPc Function in Physiology and Prion Pathogenesis -- Structure of PrPc and PrPsc -- Models of PrPsc Aggregates -- Prion Replication -- Conclusion -- Acknowledgments -- References -- Chapter IX Transmissible Spongiform Encephalopathy (TSE) -- Abstract -- Introduction -- Transmission of TSEs -- Species Barrier -- Prion Strain -- Prion Pathogenesis. 327 $aTSEs in Humans and Animals -- Clinical and Pathological Features -- Human TSEs -- Idiopathic TSEs: sCJD and Sporadic Fatal Insomnia -- Inherited TSEs: fCJD, GSS and FFI -- Acquired TSEs: kuru, iCJD, and vCJD -- Animal TSes -- Scrapie -- BSE -- CWD -- Other Animal TSEs -- Conclusion -- Acknowledgments -- References -- Chapter X Diagnostic Microbiology -- Abstract -- Introduction -- Direct Examination and Antigen Testing -- Microscopic Examination -- Common Stain Methods -- Biochemical and Antigen Testing -- Microorganism and Virus Culture -- Primary Alive Culture -- Culture using Living Cells -- Immunological Diagnosis -- Immunofluorescence Methods -- Enzyme Immunoassays -- Immunoblotting -- Other Serologic Techniques -- Molecular Diagnosis -- Nucleic Acid Extraction -- Non-Amplified Probe Methods -- Amplification Methods -- Signal Amplification -- PCR-Target Amplification -- Real Time PCR -- Post Amplification Analyses -- Colorimetric ELISA -- Reverse Hybridization -- Solid Nucleic Acid Arrays -- Suspension Array Analysis -- Sequencing -- Conclusion -- Acknowledgments -- References -- Index. 410 0$aImmunology and Immune System Disorders 606 $aMolecular microbiology 606 $aCommunicable diseases$xMolecular aspects 606 $aPathology, Molecular 615 0$aMolecular microbiology. 615 0$aCommunicable diseases$xMolecular aspects. 615 0$aPathology, Molecular. 676 $a616.9/0471 701 $aSaleh$b Mazen T$01704018 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910809637103321 996 $aMolecular aspects of infectious disease$94089689 997 $aUNINA