LEADER 04211nam 2200673Ia 450 001 9910809522103321 005 20200520144314.0 010 $a1-282-03782-X 010 $a9786612037825 010 $a0-387-78887-5 024 7 $a10.1007/978-0-387-78887-6 035 $a(CKB)1000000000714931 035 $a(EBL)428983 035 $a(OCoLC)317883273 035 $a(SSID)ssj0000134331 035 $a(PQKBManifestationID)11954063 035 $a(PQKBTitleCode)TC0000134331 035 $a(PQKBWorkID)10053860 035 $a(PQKB)10839705 035 $a(DE-He213)978-0-387-78887-6 035 $a(MiAaPQ)EBC428983 035 $a(Au-PeEL)EBL428983 035 $a(CaPaEBR)ebr10282495 035 $a(CaONFJC)MIL203782 035 $a(PPN)132863510 035 $a(EXLCZ)991000000000714931 100 $a20080409d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCyclin dependent kinase 5 (Cdk5) /$fNancy Y. Ip, Li-Huei Tsai, editors 205 $a1st ed. 2008. 210 $aNew York ;$aLondon $cSpringer$dc2008 215 $a1 online resource (325 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-8774-6 311 $a0-387-78886-7 327 $aCdk5/p35 Regulates Neuronal Migration -- CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration -- Cdk5 in Presynapses -- Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release -- Cdk5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling -- Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival -- CDK5 and Mitochondrial Cell Death Pathways -- Regulation and Function of Cdk5 in the Nucleus -- Cdk5 May Be an Atypical Kinase, but Not in the Way You Think -- Cdk5 and Neuregulin-1 Signaling -- Cyclin-Dependent Kinase 5 and Insulin Secretion -- Protein?Protein Interactions Involving the N-Terminus of p35 -- The Kinase Activity of Cdk5 and Its Regulation -- The Structural Bases of CDK5 Activity -- Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting -- Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory -- Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration -- Cdk5 as a Drug Target for Alzheimer?s Disease. 330 $aCyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases. 606 $aCyclin-dependent kinases$xInhibitors$xTherapeutic use 606 $aCyclin-dependent kinases 606 $aNervous system$xDegeneration$xEtiology 606 $aNervous system$xDegeneration$xTreatment 615 0$aCyclin-dependent kinases$xInhibitors$xTherapeutic use. 615 0$aCyclin-dependent kinases. 615 0$aNervous system$xDegeneration$xEtiology. 615 0$aNervous system$xDegeneration$xTreatment. 676 $a616.80471 701 $aIp$b Nancy Yuk-Yu$01721499 701 $aTsai$b Li-Huei$01721500 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910809522103321 996 $aCyclin dependent kinase 5 (Cdk5)$94121162 997 $aUNINA