LEADER 01496nam 2200481 450 001 9910809397503321 005 20230617012627.0 010 $a1-78920-574-3 010 $a1-84545-104-X 010 $a1-84545-026-4 035 $a(CKB)2560000000322286 035 $a(SSID)ssj0000383540 035 $a(PQKBManifestationID)12137273 035 $a(PQKBTitleCode)TC0000383540 035 $a(PQKBWorkID)10330526 035 $a(PQKB)10887776 035 $a(MiAaPQ)EBC5774269 035 $a(EXLCZ)992560000000322286 100 $a20190529d2005 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMultiple medical realities $epatients and healers in biomedical, alternative, and traditional medicine /$fedited by Helle Johannessen and Imre La?za?r 210 1$aNew York ;$aLondon :$cBerghahn Books,$d[2005] 210 4$dİ2005 215 $a1 online resource (xiii, 202 pages) $cillustrations, maps 225 1 $aEASA series ;$v4 300 $aBibliographic Level Mode of Issuance: Monograph 410 0$aEASA series ;$v4. 606 $aAlternative medicine$vCross-cultural studies 615 0$aAlternative medicine 676 $a615.8/8 702 $aJohannessen$b Helle 702 $aLa?za?r$b Imre$f1957- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910809397503321 996 $aMultiple medical realities$94008134 997 $aUNINA LEADER 06295nam 2200541Ia 450 001 9910828752503321 005 20200520144314.0 010 $a0-19-756122-5 010 $a1-280-47118-2 010 $a9786610471188 010 $a1-60256-264-4 035 $a(CKB)1000000000028880 035 $a(SSID)ssj0000140404 035 $a(PQKBManifestationID)11144734 035 $a(PQKBTitleCode)TC0000140404 035 $a(PQKBWorkID)10051450 035 $a(PQKB)10587475 035 $a(MiAaPQ)EBC3051933 035 $a(EXLCZ)991000000000028880 100 $a19910920e19921990 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDNA fingerprinting $ean introduction /$fLorne T. Kirby 205 $a1st ed. 210 $aNew York $cW.H. Freeman$d1992 215 $a1 online resource (382 pages) 300 $aOriginally published: New York : Stockton Press, c1990. 311 $a0-19-511867-7 320 $aIncludes bibliographical references and index. 327 $aIntro -- CONTENTS -- 1. INTRODUCTION -- DEFINITION -- HISTORY -- A CASE FOR DNA -- APPLICATIONS -- REFERENCES -- 2. GENETIC PRINCIPLES -- DNA STRUCTURE -- Nuclear DNA -- Organelle DNA -- DNA FUNCTION -- REPRODUCTION -- LINKAGE -- PEDIGREE ANALYSIS -- MUTATION -- RESTRICTION ENDONUCLEASES -- CONCEPT OF POLYMORPHISM -- RECOMBINANT DNA -- BASE SEQUENCE DETERMINATION -- OLIGONUCLEOTIDE SYNTHESIS -- REPETITIVE SEQUENCE ORGANIZATION -- NOMENCLATURE OF ARBITRARY DNA SEGMENTS -- REFERENCES -- 3. LABORATORY ORGANIZATION -- LABORATORY SECTIONS -- Office -- Specimen Documentation -- Specimen Processing -- General Preparation -- Vector Handling -- Amplification by PCR -- Hybridization and Radioisotope Handling -- Darkroom -- Result Interpretation -- Tissue Culture -- Wash-up Area -- EQUIPMENT SUMMARY -- OPERATION -- Personnel -- Work Flow -- Safety -- REFERENCES -- 4. SPECIMENS -- COLLECTION -- STORAGE AND TRANSPORT -- DNA EXTRACTION -- Principles -- Automated System -- Manual System Organic Solvent Extraction -- Manual System Nonorganic Solvent Extraction -- DIALYSIS -- RNAASE TREATMENT -- QUANTITATION -- DNA CONCENTRATION -- QUALITY DETERMINATION -- EFFECTS OF ENVIRONMENTAL FACTORS INCLUDING CONTAMINATING DNA ON DNA PROFILES -- ANALYSIS REAGENTS -- REFERENCES -- 5. DNA AMPLIFICATION -- POLYMERASE CHAIN REACTION -- Amplified Fragment Length Polymorphisms (AMP-FLPs) -- Advantages of PCR -- Pitfalls in PCR -- A PCR Protocol -- PROBE AMPLIFICATION -- TISSUE CULTURE -- REFERENCES -- 6. ANALYSIS TECHNIQUES -- RESTRICTION ENZYME CLEAVAGE -- GEL-BLOT ORGANIZATION -- Forensic -- Parentage -- Size Markers -- ELECTROPHORESIS -- Equipment -- Reagents -- Procedure -- PHOTOGRAPHY -- DNA RECOVERY -- MEMBRANE TRANSFER -- Southern Blots -- Dot-(Slot-) Blots -- RADIOISOTOPE PROBE LABELING -- NONRADIOISOTOPE PROBE LABELING -- HYBRIDIZATION -- Principles -- Procedures. 327 $aPCR Products -- PRINT DETECTION -- BLOT STRIPPING AND REPROBING -- DATA PROCESSING -- Allele Fragment Size Determination -- Digital Analysis -- The FBI System -- Interpretation of Profile Matches -- PROFILE REPORT -- DNA PROFILE DATA BASES -- POTENTIAL PITFALLS -- TROUBLESHOOTING GUIDE -- ANALYSIS COST -- ANALYSIS REAGENTS -- REFERENCES -- 7. PROBES, ALLELE MUTATIONS, AND RESTRICTION ENZYMES -- PROBES -- Polymorphism -- Tandem Repeat Single-Locus vs. Multilocus Probes -- Oligonucleotide Probes -- Amplification and Stability -- Availability -- Probes Used in Forensic Analysis -- MUTATIONS -- Allele Formation -- Genotype Analysis -- RESTRICTION ENZYMES -- Recognition Site Features -- Fragment Resolution -- Sensitivity to Inhibitors and Stability -- Price and Availability -- The Enzymes Selected for Forensic Analysis -- REFERENCES -- 8. PROBABILITY AND STATISTICAL ANALYSIS -- STATISTICAL METHODOLOGY -- Random Sampling -- Data Presentation -- Summary Statistics -- Statistical Inference -- Hypothesis testing -- PROBABILITY -- Probability of Combined Events: Addition and Multiplication Rules -- Bayes' Theorem and Revision of Probabilities -- Random Variables and Distributions -- Genetic Applications of Probability -- REFERENCES -- 9. QUALITY CONTROL -- DNA TEST SYSTEM STANDARDS -- CORRECT SPECIMEN -- DNA QUALITY -- DNA CONTAMINATION -- ANALYSIS CONTROL -- SHEWHART SYSTEM -- RESULT INTERPRETATION -- REFERENCES -- 10. LEGAL AND ETHICAL CONSIDERATIONS -- THE IMPACT OF DNA TYPING -- THE LEGAL STANDARDS FOR ADMISSIBILITY OF DNA TYPING -- The Frye Test -- Ascertaining General Acceptance -- Proper Application of the Technique -- The Relevancy Test of Admissibility -- Another Approach -- Legislated Admissibility of DNA Typing -- DNA Data Banking -- LEGAL FOUNDATION FOR GENERAL ADMISSIBILITY -- Obtaining Known and Unknown Biological Samples -- Chain of Custody. 327 $aProper Laboratory Procedures -- PROCEDURAL AND ETHICAL CONCERNS -- Procedural Safeguards -- Ethical Concerns -- CONCLUSION -- NOTES -- 11. CASE APPLICATIONS -- FORENSIC -- Cases -- PARENTAGE -- Cases -- MEDICAL -- Applications -- ANIMAL SCIENCES -- Cases -- WILDLIFE POACHING -- The Smoking Gun -- PLANT SCIENCES -- FUTURE -- REFERENCES -- APPENDIX I: GUIDELINES FOR A QUALITY ASSURANCE PROGRAM FOR DNA RESTRICTION FRAGMENT LENGTH POLYMORPHISM ANALYSIS -- APPENDIX II: THE COMBINED DNA INDEX SYSTEM (CODIS): A THEORETICAL MODEL -- APPENDIX III: SUPPLIERS OF DNA ANALYSIS EQUIPMENT, PRODUCTS, OR SERVICES -- GLOSSARY -- A -- B -- C -- D -- E -- F -- G -- H -- I -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z -- ABBREVIATIONS AND SYMBOLS -- NAME INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z -- SUBJECT INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- Z. 606 $aDNA fingerprinting 606 $aForensic genetics$xTechnique 615 0$aDNA fingerprinting. 615 0$aForensic genetics$xTechnique. 676 $a614/.1 700 $aKirby$b Lorne T.$f1938-$01760469 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828752503321 996 $aDNA fingerprinting$94199455 997 $aUNINA