LEADER 05466nam 2200541 a 450 001 9910809373703321 005 20240418060015.0 010 $a0-8166-6853-1 035 $a(CKB)1000000000487256 035 $a(SSID)ssj0000252980 035 $a(PQKBManifestationID)11220698 035 $a(PQKBTitleCode)TC0000252980 035 $a(PQKBWorkID)10185703 035 $a(PQKB)10292994 035 $a(MiAaPQ)EBC345341 035 $a(Au-PeEL)EBL345341 035 $a(CaPaEBR)ebr10231306 035 $a(CaONFJC)MIL526072 035 $a(OCoLC)476161563 035 $a(EXLCZ)991000000000487256 100 $a19851217d1965 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStudies in the metabolism of vitamin B12 /$fAlfred Doscherholmen 205 $a1st ed. 210 1$aMinneapolis :$cUniversity of Minnesota Press,$d[1965] 215 $aviii, 271 pages $cillustrations 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a0-8166-0339-1 311 0 $a0-8166-6216-9 320 $aIncludes bibliographical references (p. 233-262) and index. 327 $aIntro -- TABLE OF CONTENTS -- Introduction and Methods Used in This Study -- INTRODUCTION AND METHODS -- The Gastrointestinal Absorption of Vitamin B[sub(12)] in Man -- 1. A REVIEW OF THE LITERATURE -- The Fecal Excretion Technique: The Heinle Test -- The Urinary Excretion Technique: The Schilling Test -- In-Vivo Measurements of Hepatic Uptake of Radioactivity: The Glass Test -- Plasma Absorption of Radiocyanocobalamin: Doscherholmen and Hagen, Booth and Mollin -- Total Body Counting -- 2.URINARY EXCRETION TESTS -- Results in Control Patients -- Results in Patients with Addison's Pernicious Anemia -- Reproducibility of the Results of the Urinary and Fecal Excretion Tests Performed Simultaneously -- Response to Intrinsic Factor in Patients with Pernicious Anemia -- Results in Patients with Total Gastrectomy -- Results in Patients with Partial Gastrectomy -- Results in Patients with Histamine-Fast Achlorhydria -- Results in Patients with Posterolateral Column Disease of the Spinal Cord -- Results in Patients with Faber's Pernicious Anemia -- Results in Patients with Various Intestinal Diseases: Regional Ileitis, Non-Tropical Sprue, and Secondary Steatorrhea -- Results in Patients with Miscellaneous Diseases -- False Positive and Negative Urinary Excretion Tests -- Results with Varying Time Intervals between the Oral Dose and the Parenteral "Flushing" Injection -- Results with Daily "Flushing" Injections for One Week -- Results with "Flushing" Doses of Varying Magnitude -- Results with Multiple "Flushing" Injections -- Results with Parenteral "Loading" Administered Simultaneously with the Oral Dose -- Results with Parenteral "Preloading" Administered 24 Hours Prior to the Oral Test -- 3. THE PLASMA ABSORPTION TEST -- Results in Control Subjects and Patients with Pernicious Anemia after Test Doses of 0.46 & -- #956. 327 $ag Vitamin B[sub(12)] Containing 0.5 & -- #956 -- c Co[sup(80)] or 0.92 & -- #956 -- g B[sub(12)] with 1.0 & -- #956 -- c Co[sup(60)] -- Comparison of the Plasma Absorption Method and the Schilling Test -- Results of the Plasma Absorption Test Using 0.56 & -- #956 -- g Cyanocobalamin Containing 0.25 & -- #956 -- c Co[sup(60)] -- Scintillation Spectrometry of Co[sup(57)]B[sub(12)] in the Diagnosis of Pernicious Anemia -- Results in Patients with Partial and Total Gastrectomy -- Results in Patients with Leukemia -- Influence of Food on the Plasma Absorption of Radiocyanocobalamin -- Results with Parenteral "Loading" Injections of Non-Labeled Vitamin B[sub(12)] -- A Dual Mechanism of Vitamin B[sub(12)] Plasma Absorption -- Delay of Absorption of Radio-Labeled Cyanocobalamin in the Intestinal Wall in the Presence of Intrinsic Factor -- 4.ABSORPTION, EXCRETION, DISTRIBUTION, AND KINETICS OF INGESTED RADIOCYANOCOBALAMIN -- Investigation of the Basic Mechanism of the Schilling Test -- Distribution of Radioactivity in Man after the Oral Ingestion of Small Test Doses of Radiocyanocobalamin -- Kinetics of Ingested Radiocyanocobalamin in Man -- Miscellaneous Studies -- 5.ENZYMATIC RELEASE OF VITAMIN B[sub(12)] BOUND EITHER TO THE INTRINSIC FACTOR OR IN THE WALL OF THE SMALL INTESTINE -- Release of Vitamin B[sub(12)] from the Intrinsic Factor -- Experiments Using Human Gastric Juice as a Source of Intrinsic Factor -- Experiments Using Rat Stomach Homogenate as a Source of Intrinsic Factor -- Experiments Using Hog Stomach IFC as a Source of IF -- Release of Co[sup(57)]B[sub(12)] from Its Binding in the Intestinal Wall -- Characterization of the Ultrafiltrable Radioactivity -- 6.TRANSPORT OF B[sub(12)] IN THE BLOOD -- Determination of Vitamin B[sub(12)] Serum Binding Capacity by Ultrafiltration. 327 $a7.ALTERATION OF HEPATIC STORAGE OF RADIOCYANOCOBALAMIN -- 8.SUMMARY -- BIBLIOGRAPHY -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W. 606 $aVitamin B12$xMetabolism 615 0$aVitamin B12$xMetabolism. 676 $a612.399 700 $aDoscherholmen$b Alfred$01605058 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910809373703321 996 $aStudies in the metabolism of vitamin B12$93930091 997 $aUNINA