LEADER 03654nam 2200613Ia 450 001 9910809188903321 005 20200520144314.0 010 $a0-674-03943-2 024 7 $a10.4159/9780674039438 035 $a(CKB)1000000000786753 035 $a(EBL)3300495 035 $a(SSID)ssj0000119393 035 $a(PQKBManifestationID)11131970 035 $a(PQKBTitleCode)TC0000119393 035 $a(PQKBWorkID)10056530 035 $a(PQKB)10903666 035 $a(Au-PeEL)EBL3300495 035 $a(CaPaEBR)ebr10318489 035 $a(OCoLC)923112038 035 $a(DE-B1597)571827 035 $a(DE-B1597)9780674039438 035 $a(MiAaPQ)EBC3300495 035 $a(OCoLC)1294424518 035 $a(EXLCZ)991000000000786753 100 $a20040316h20022000 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe century of the gene /$fEvelyn Fox Keller 205 $a1st ed. 210 $aCambridge, Mass. $cHarvard University Press$d2002, c2000 215 $a1 online resource (192 p.) 300 $aDescription based upon print version of record. 311 $a0-674-00372-1 311 $a0-674-00825-1 320 $aIncludes bibliographical references (p. [169]-182) and index. 327 $tFrontmatter --$tCONTENTS --$tIntroduction: The Life of a Powerful Word --$t1. Motors of Stasis and Change: The Regulation of Genetic Stability --$t2. The Meaning of Gene Function: What Does a Gene Do? --$t3. The Concept of a Genetic Program: How to Make an Organism --$t4. Limits of Genetic Analysis: What Keeps Development on Track? --$tConclusion: What Are Genes For? --$tNotes --$tReferences --$tAcknowledgments --$tIndex 330 $aIn a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology?s progress from gene to genome in one hundred years, The Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene?word and object?as the core explanatory concept of heredity and development. She argues that we need a new vocabulary that includes concepts such as robustness, fidelity, and evolvability. But more than a new vocabulary, a new awareness is absolutely crucial: that understanding the components of a system (be they individual genes, proteins, or even molecules) may tell us little about the interactions among these components. With the Human Genome Project nearing its first and most publicized goal, biologists are coming to realize that they have reached not the end of biology but the beginning of a new era. Indeed, Keller predicts that in the new century we will witness another Cambrian era, this time in new forms of biological thought rather than in new forms of biological life. 606 $aGenetics$xHistory$y20th century 606 $aBiology$xHistory 615 0$aGenetics$xHistory 615 0$aBiology$xHistory. 676 $a576.5 686 $aWB 2415$2rvk 700 $aKeller$b Evelyn Fox$f1936-$051484 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910809188903321 996 $aThe century of the gene$94196531 997 $aUNINA