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010   $a9786613143440
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100   $a20110714d2011      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aDNA deamination and the immune system $eAID in health and disease /$feditors, Sebastian Fugmann, Marilyn Diaz, Nina Papavasiliou
205   $a1st ed.
210   $aLondon $cImperial College Press$d2011
215   $a1 online resource (232 p.)
225 1 $aMolecular medicine and medicinal chemistry ;$vv. 3
300   $aDescription based upon print version of record.
311   $a1-84816-592-7 
320   $aIncludes bibliographical references and index.
327   $aPreface; Contents; List of Tables; List of Figures; Chapter 1 Introduction; Chapter 2 Switch Regions, ChromatinAccessibility and AID Targeting; Chapter 3 Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Chapter 4 Partners in Diversity: The Search for AID Co-Factors; Chapter 5 Resolution of AID Lesions in Class Switch Recombination; Chapter 6 Error-Prone and Error-Free Resolution of AID Lesions in SHM; Chapter 7 Regulatory Mechanisms of AID Function; Chapter 8 AID in Immunodeficiency and Cancer; Chapter 9 AID in Aging and in Autoimmune Disease; Index
330   $aThis book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted 
410  0$aMolecular medicine and medicinal chemistry ;$vv. 3.
606   $aDNA
606   $aImmune system
615  0$aDNA.
615  0$aImmune system.
676   $a571.967
701   $aFugmann$b Sebastian$01666723
701   $aDiaz$b Marilyn$01666724
701   $aPapavasiliou$b Nina$01666725
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910809152503321
996   $aDNA deamination and the immune system$94026121
997   $aUNINA