LEADER 04520nam 2200529 a 450 001 9910808830503321 005 20230721014248.0 010 $a1-61324-474-6 035 $a(CKB)2670000000095652 035 $a(EBL)3019634 035 $a(SSID)ssj0000522129 035 $a(PQKBManifestationID)12179972 035 $a(PQKBTitleCode)TC0000522129 035 $a(PQKBWorkID)10527870 035 $a(PQKB)10322412 035 $a(MiAaPQ)EBC3019634 035 $a(Au-PeEL)EBL3019634 035 $a(CaPaEBR)ebr10671199 035 $a(OCoLC)738478182 035 $a(EXLCZ)992670000000095652 100 $a20090625d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug resistant neoplasms$b[electronic resource] /$fEthan G. Verrite, editor 210 $aNew York $cNova Science Publishers$dc2009 215 $a1 online resource (269 p.) 225 1 $aCancer etiology, diagnosis and treatments series 300 $aDescription based upon print version of record. 311 $a1-60741-255-1 320 $aIncludes bibliographical references and index. 327 $aTherapeutic implications of the intrinsic and acquired resistance of cancer stem/progenitor cells in inefficacy of current cancer treatments and disease relapse / Murielle Mimeault and Surinder K. Batra -- Role of O6-methyl guanine-DNA methyl transferase and the effect of O6-benzylguanine in cancer chemotherapy / Jun Murakami ... [et al.] -- The role of tumoural micro-environment and its vasculature on chemotherapy drug resistance: the potential for it's modulation to achieve therapeutic gain / A. Weickhardt and M. Michael -- Inherent and microenvironment-mediated mechanisms of drug resistance / Malathy P.V Shekhar -- Studies on the mechanisms of acquired resistance to EGFR tyrosine kinase inhibitor gefitinib in NSCLC cell lines: evidence that ligand-induced endocytosis of EGFR via the early/late endocytic pathway is associated with gefitinib sensitivity of NSCLC cell line / Yukio Nishimura -- Mechanisms of resistance to EGF receptor-tyrosine kinase inhibitor in NSCLC cell lines: gefitinib sensitivity is closely correlated with ligand-induced endocytosis of phosphorylated EGF receptor / Yukio Nishimura, Kiyoko Yoshioka and Kazuyuki Itoh -- Targeting adverse features of hormone-resistant breast cancer / Stephen Hiscox ... [et al.] -- Systematic analysis of patterns of cross resistance between anticancer agents / Britta Stordal and Ross Davey -- Molecular structure and energy: clinical importance in drug resistant neoplasms / Viroj Wiwanitkit -- Treating drug resistant malignancy / Viroj Wiwanitkit -- Overcoming ovarian cancer drug resistance with phytochemicals and other compounds / Marion M. Chan and Dunne Fong -- New research communications on cancer drug resistance, assessment of cancer drug resistance with nuclear medicine images / Seigo Kinuya. 330 $a"One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Frequently, resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells. Studies on the mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and its implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field"--Publisher's description. 410 0$aCancer etiology, diagnosis, and treatments. 606 $aDrug resistance in cancer cells 615 0$aDrug resistance in cancer cells. 676 $a616.99/4061 701 $aVerrite$b Ethan G$01681752 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808830503321 996 $aDrug resistant neoplasms$94051362 997 $aUNINA