LEADER 03176nam 2200625 a 450 001 9910808689303321 005 20240516100650.0 010 $a1-280-59238-9 010 $a9786613622211 010 $a1-118-30983-9 010 $a1-118-30987-1 010 $a1-118-30986-3 035 $a(CKB)2670000000203832 035 $a(EBL)832598 035 $a(OCoLC)793995928 035 $a(SSID)ssj0000632078 035 $a(PQKBManifestationID)11386458 035 $a(PQKBTitleCode)TC0000632078 035 $a(PQKBWorkID)10599598 035 $a(PQKB)11718969 035 $a(MiAaPQ)EBC832598 035 $a(Au-PeEL)EBL832598 035 $a(CaPaEBR)ebr10643080 035 $a(CaONFJC)MIL362221 035 $a(PPN)178931357 035 $a(EXLCZ)992670000000203832 100 $a20111116d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aApplications of transition metal catalysis in drug discovery and development $ean industrial perspective /$fedited by Matthew L. Crawley, Barry M. Trost 205 $a1st ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2012 215 $a1 online resource (376 p.) 300 $aDescription based upon print version of record. 311 $a0-470-63132-5 320 $aIncludes bibliographical references and index. 327 $aTransition metal catalysis in the pharmaceutical industry / Carl A. Busacca ... [et al.] -- Selected applications of transition metal-catalyzed carbon-carbon cross-coupling reactions in the pharmaceutical industry / Hong C. Shen -- Selected applications of Pd and Cu-catalyzed carbon-heteroatom cross-coupling reactions in the pharmaceutical industry / Jingjun Yin -- Asymmetric cross-coupling reactions / William A. Szabo and Vince Yeh -- Metathesis / Oliver Thiel -- Transition metal-catalyzed synthesis of five and six membered heterocycles / Cheol K. Chung and Matthew L. Crawley -- Oxidative catalysis / Lamont Terrell -- Industrial asymmetric hydrogenation / Hans-Ulrich Blaser. 330 $aThis book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery 606 $aDrug development 606 $aTransition metal catalysts 615 0$aDrug development. 615 0$aTransition metal catalysts. 676 $a615.1/9 701 $aCrawley$b Matthew L$01718969 701 $aTrost$b Barry M$091554 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808689303321 996 $aApplications of transition metal catalysis in drug discovery and development$94116360 997 $aUNINA