LEADER 03424nam 2200505 450 001 9910808626103321 005 20230807215422.0 010 $a0-309-36786-7 010 $a0-309-36784-0 035 $a(CKB)3710000000411292 035 $a(Au-PeEL)EBL3439684 035 $a(CaPaEBR)ebr11052991 035 $a(OCoLC)911194435 035 $a(MiAaPQ)EBC3439684 035 $a(EXLCZ)993710000000411292 100 $a20150523h20152015 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aPotential risks and benefits of gain-of-function research $esummary of workshop /$fFrances Sharples [and three others], rapporteurs ; National Research Council. Board on Life Sciences ; National Research Council. Committee on Science, Technology, and Law ; Institute of Medicine. Board on Health Sciences Policy 210 1$aWashington, District of Columbia :$cThe National Academies Press,$d2015. 210 4$dİ2015 215 $a1 online resource (140 pages) 311 $a0-309-36780-8 311 $a0-309-36783-2 320 $aIncludes bibliographical references. 330 $a"On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting."--$cPublisher's description. 606 $aEpidemics$zUnited States$xPrevention 607 $aUnited States$2fast 615 0$aEpidemics$xPrevention. 676 $a362.19620300973 700 $aSharples$b Frances Ellen$01662488 702 $aSharples$b Frances 712 02$aNational Research Council (U.S.).$bBoard on Life Sciences. 712 02$aNational Research Council (U.S.).$bCommittee on Science, Technology, and Law. 712 02$aInstitute of Medicine (U.S.).$bBoard on Health Sciences Policy. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808626103321 996 $aPotential risks and benefits of gain-of-function research$94111416 997 $aUNINA