LEADER 05426nam 22005175 450 001 9910808509303321 005 20230120113118.0 010 $a3-031-01653-X 024 7 $a10.1007/978-3-031-01653-0 035 $a(CKB)5580000000323330 035 $a(DE-He213)978-3-031-01653-0 035 $a(MiAaPQ)EBC919749 035 $a(EXLCZ)995580000000323330 100 $a20220601d2012 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aChronobioengineering$b[electronic resource] $eIntroduction to Biological Rhythms with Applications, Volume 1 /$fby Donald McEachron 205 $a1st ed. 2012. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2012. 215 $a1 online resource (XXIV, 264 p.) 225 1 $aSynthesis Lectures on Biomedical Engineering,$x1930-0336 311 $a3-031-00525-2 327 $aTime and Time Again -- Walking on Air: An Empirical Proof-of-Concept -- Clock Tech, Part 1 -- Clock Tech II From External to Internal Timers -- Clock Tech III Rise of the CircaRhythms -- The Circle Game: Mathematics, Models, and Rhythms -- The Power of Circular Reasoning. 330 $aThis book represents the first in a two-volume set on biological rhythms. This volume focuses on supporting the claim that biological rhythms are universal and essential characteristics of living organisms, critical for proper functioning of any living system. The author begins by examining the potential reasons for the evolution of biological rhythms: (1) the need for complex, goal-oriented devices to control the timing of their activities; (2) the inherent tendency of feedback control systems to oscillate; and (3) the existence of stable and powerful geophysical cycles to which all organisms must adapt. To investigate the second reason, the author enlists the help of biomedical engineering students to develop mathematical models of various biological systems. One such model involves a typical endocrine feedback system. By adjusting various model parameters, it was found that creating a oscillation in any component of the model generated a rhythmic cascade that made the entire system oscillate. This same approach was used to show how daily light/dark cycles could cascade rhythmic patterns throughout ecosystems and within organisms. Following up on these results, the author discusses how the twin requirements of internal synchronization (precise temporal order necessary for the proper functioning of organisms as complex, goal-oriented devices) and external synchronization (aligning organisms' behavior and physiology with geophysical cycles) supported the evolution of biological clocks. The author then investigates the clock systems that evolved using both conceptual and mathematical models, with the assistance of Dr. Bahrad Sokhansanj, who contributes a chapter on mathematical formulations and models of rhythmic phenomena. With the ubiquity of biological rhythms established, the author suggests a new classification system: the F4LM approach (Function; Frequency; waveForm; Flexibility; Level of biological system expressing rhythms; and Mode of rhythm generation) to investigate biological rhythms. This approach is first used on the more familiar cardiac cycle and then on neural rhythms as exemplified and measured by the electroencephalogram. During the process of investigating neural cycles, the author finds yet another reason for the evolution of biological rhythms: physical constraints, such as those imposed upon long distance neural signaling. In addition, a common theme emerges of a select number of autorhythmic biological oscillators imposing coherent rhythmicity on a larger network or system. During the course of the volume, the author uses a variety of observations, models, experimental results, and arguments to support the original claim of the importance and universality of biological rhythms. In Volume 2, the author will move from the establishment of the critical nature of biological rhythms to how these phenomena may be used to improve human health, well-being, and productivity. In a sense, Volume 1 focuses on the chronobio aspect of chronobioengineering while Volume 2 investigates methods of translating this knowledge into applications, the engineering aspect of chronobioengineering. Table of Contents: Time and Time Again / Walking on Air: An Empirical Proof-of-Concept / Clock Tech, Part 1 / Clock Tech II From External to Internal Timers / Clock Tech III Rise of the CircaRhythms / The Circle Game: Mathematics, Models, and Rhythms / The Power of Circular Reasoning. 410 0$aSynthesis Lectures on Biomedical Engineering,$x1930-0336 606 $aEngineering 606 $aBiophysics 606 $aBiomedical engineering 606 $aTechnology and Engineering 606 $aBiophysics 606 $aBiomedical Engineering and Bioengineering 615 0$aEngineering. 615 0$aBiophysics. 615 0$aBiomedical engineering. 615 14$aTechnology and Engineering. 615 24$aBiophysics. 615 24$aBiomedical Engineering and Bioengineering. 676 $a620 700 $aMcEachron$b Donald$4aut$4http://id.loc.gov/vocabulary/relators/aut$01645418 906 $aBOOK 912 $a9910808509303321 996 $aChronobioengineering$93991875 997 $aUNINA