LEADER 05719nam 2200745Ia 450 001 9910808104203321 005 20200520144314.0 010 $a3-527-64784-8 010 $a1-280-66359-6 010 $a9786613640529 010 $a3-527-64782-1 010 $a3-527-64785-6 035 $a(CKB)2670000000170280 035 $a(EBL)882609 035 $a(OCoLC)784885989 035 $a(SSID)ssj0000663497 035 $a(PQKBManifestationID)11371024 035 $a(PQKBTitleCode)TC0000663497 035 $a(PQKBWorkID)10602764 035 $a(PQKB)10943066 035 $a(MiAaPQ)EBC882609 035 $a(Au-PeEL)EBL882609 035 $a(CaPaEBR)ebr10560643 035 $a(CaONFJC)MIL364052 035 $a(PPN)179027778 035 $a(EXLCZ)992670000000170280 100 $a20120126d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMicrowaves in organic and medicinal chemistry /$fC. Oliver Kappe, Alexander Stadler and Doris Dallinger 205 $a2nd ed. 210 $aWeinheim $cWiley-VCH$dc2012 215 $a1 online resource (686 p.) 225 1 $aMethods and principles in medicinal chemistry ;$vv. 52 300 $aPrevious ed.: 2005. 311 $a3-527-33185-9 320 $aIncludes bibliographical references and index. 327 $aMicrowaves in Organic and Medicinal Chemistry; Contents; Preface; Personal Foreword to the First Edition; Personal Foreword to the Second Edition; 1 Introduction: Microwave Synthesis in Perspective; 1.1 Microwave Synthesis and Medicinal Chemistry; 1.2 Microwave-Assisted Organic Synthesis (MAOS): A Brief History; 1.3 Scope and Organization of the Book; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry 327 $a2.5.2 Thermal Effects (Kinetics)2.5.3 Specific Microwave Effects; 2.5.4 Nonthermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens; 3.3 Dedicated Microwave Reactors for Organic Synthesis; 3.4 Single-Mode Instruments; 3.4.1 Anton Paar GmbH; 3.4.1.1 Monowave 300; 3.4.2 Biotage AB; 3.4.2.1 Initiator Platform; 3.4.2.2 Chemspeed SWAVE; 3.4.2.3 Peptide Synthesizers; 3.4.3 CEM Corporation; 3.4.3.1 Discover Platform; 3.4.3.2 Explorer Systems; 3.4.3.3 Voyager System; 3.4.3.4 Peptide Synthesizers; 3.5 Multimode Instruments 327 $a3.5.1 Anton Paar GmbH3.5.1.1 Synthos 3000; 3.5.1.2 Masterwave Benchtop Reactor; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l; 3.5.4.1 MultiSYNTH System; 3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 Microwave-Heated Autoclave Systems; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-pressurized Reaction Vessels; 4.5 Nonclassical Solvents 327 $a4.5.1 Water as Solvent 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods; 4.7.2.1 Solid-Phase Synthesis; 4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts, and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop-Flow Techniques 327 $a4.8.4 Microwave Reactor Systems for Production Scale References; 5 Literature Survey Part A: Transition Metal-Catalyzed Reactions; 5.1 General Comments; 5.2 Carbon-Carbon Bond Formations; 5.2.1 Heck Reactions; 5.2.2 Suzuki-Miyaura Reactions; 5.2.3 Sonogashira Reactions; 5.2.4 Stille Reactions; 5.2.5 Negishi, Kumada, and Related Reactions; 5.2.6 Carbonylation Reactions; 5.2.7 Asymmetric Allylic Alkylations; 5.2.8 Miscellaneous Carbon-Carbon Bond-Forming Reactions; 5.3 Carbon-Heteroatom Bond Formations; 5.3.1 Buchwald-Hartwig Reactions; 5.3.2 Ullmann Condensation Reactions 327 $a5.3.3 Miscellaneous Carbon-Heteroatom Bond-Forming Reactions 330 $aTailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation and equipment. The main part of the book then goes on to systematically survey the complete range of published microwave-assisted synthesis methods from their beginnings in the 1990's to mid-2011, drawing on data from more than 5,000 reports 410 0$aMethods and principles in medicinal chemistry ;$vv. 52. 606 $aMicrowaves 606 $aOrganic compounds$xSynthesis 606 $aPharmaceutical chemistry 615 0$aMicrowaves. 615 0$aOrganic compounds$xSynthesis. 615 0$aPharmaceutical chemistry. 676 $a615.19 700 $aKappe$b C. Oliver$01688461 701 $aDallinger$b Doris$01688462 701 $aStadler$b Alexander$f1973-$01688463 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808104203321 996 $aMicrowaves in organic and medicinal chemistry$94062716 997 $aUNINA