LEADER 04040nam 2200577 450 001 9910807756203321 005 20230120002246.0 010 $a0-12-801959-X 035 $a(CKB)3710000000337361 035 $a(EBL)1921148 035 $a(SSID)ssj0001432653 035 $a(PQKBManifestationID)11759441 035 $a(PQKBTitleCode)TC0001432653 035 $a(PQKBWorkID)11405722 035 $a(PQKB)11182475 035 $a(MiAaPQ)EBC1921148 035 $a(Au-PeEL)EBL1921148 035 $a(CaPaEBR)ebr11006351 035 $a(CaONFJC)MIL695234 035 $a(OCoLC)900464416 035 $a(EXLCZ)993710000000337361 100 $a20150127h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aChemical modulators of protein misfolding and neurodegenerative disease /$fPierfausto Seneci 210 1$aLondon, England :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (260 p.) 300 $aDescription based upon print version of record. 311 $a1-322-63952-3 311 $a0-12-801944-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau; 1.1 - Tau-targeted compounds; 1.1.1 - Tau Kinase Inhibitors; 1.1.2 - Tau O-GlcNAcylation Enhancers; 1.1.3 - Microtubule (MT)-binding Compounds; 1.2 - Ab-targeted compounds; 1.2.1 - ?-Secretase Inhibitors (GSIs) and Modulators (GSMs); 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds; References; Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery; 2.1 - Molecular chaperones, pqc, and neurodegeneration 327 $a2.2 - Hsp272.3 - Hsp70; 2.3.1 - Hsp70 Inhibitors; 2.3.2 - Hsp70-BAG-1 Inhibitors; 2.4 - Hsp90; 2.4.1 - Hsp90 Inhibitors; 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition; 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition; 2.5 - Recap; References; Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 - UPS-mediated degradation of misfolded proteins; 3.2 - CHIP; 3.3 - USP14; 3.4 - Recap; References; Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates; 4.1 - Macroautophagy mediated degradation of protein aggregates; 4.2 - mTORC1 327 $a4.3 - Small molecule enhancers of rapamycin (sMERs)4.4 - Recap; References; Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates; 5.1 - Aggrephagy-mediated degradation of protein aggregates; 5.2 - p62; 5.3 - HDAC6; 5.4 - Recap; References; Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates; 6.1 - Disordered protein aggregates and ordered amyloid fibrils; 6.2 - Interfering with (neuro)toxic tau species in the aggregation process; 6.3 - Hsp110-driven disaggregation; 6.4 - Recap; References; Index 330 $a This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecula 606 $aNervous system$xDegeneration 615 0$aNervous system$xDegeneration. 676 $a616.8047 700 $aSeneci$b Pierfausto$0542916 701 $aSeneci$b Pierfausto$f1960-$0542916 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910807756203321 996 $aChemical modulators of protein misfolding and neurodegenerative disease$94020085 997 $aUNINA