LEADER 04728nam 2200661 450 001 9910807350503321 005 20200520144314.0 010 $a1-118-83630-8 010 $a1-118-83650-2 010 $a1-118-83632-4 035 $a(CKB)3710000000093187 035 $a(EBL)1650866 035 $a(SSID)ssj0001131966 035 $a(PQKBManifestationID)11627931 035 $a(PQKBTitleCode)TC0001131966 035 $a(PQKBWorkID)11148656 035 $a(PQKB)10800144 035 $a(OCoLC)861789137 035 $a(MiAaPQ)EBC1650866 035 $a(DLC) 2013043100 035 $a(Au-PeEL)EBL1650866 035 $a(CaPaEBR)ebr10849251 035 $a(CaONFJC)MIL584561 035 $a(PPN)224777955 035 $a(EXLCZ)993710000000093187 100 $a20140326h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCyclic-nucleotide phosphodiesterases in the central nervous system $efrom biology to drug discovery /$fedited by Nicholas J. Brandon, Anthony R. West 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (402 p.) 225 1 $aWiley Series in Drug Discovery and Development 300 $aDescription based upon print version of record. 311 $a0-470-56668-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPhosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin. 330 $aThis book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studi 410 0$aWiley series in drug discovery and development. 606 $aCyclic nucleotide phosphodiesterases 606 $aCentral nervous system$xPhysiology 606 $aNucleotides, Cyclic 615 0$aCyclic nucleotide phosphodiesterases. 615 0$aCentral nervous system$xPhysiology. 615 0$aNucleotides, Cyclic. 676 $a612.01513 702 $aBrandon$b Nicholas J. 702 $aWest$b Anthony R.$f1970- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910807350503321 996 $aCyclic-nucleotide phosphodiesterases in the central nervous system$94090168 997 $aUNINA