LEADER 04509nam 2200601 a 450 001 9910807236103321 005 20240417004942.0 010 $a0-309-15235-6 010 $a1-282-55435-2 010 $a9786612554353 010 $a0-309-15095-7 035 $a(CKB)2560000000014510 035 $a(EBL)3378601 035 $a(SSID)ssj0000427213 035 $a(PQKBManifestationID)11315811 035 $a(PQKBTitleCode)TC0000427213 035 $a(PQKBWorkID)10391169 035 $a(PQKB)10500302 035 $a(MiAaPQ)EBC3378601 035 $a(Au-PeEL)EBL3378601 035 $a(CaPaEBR)ebr10379894 035 $a(CaONFJC)MIL255435 035 $a(OCoLC)923281617 035 $a(EXLCZ)992560000000014510 100 $a20100514d2010 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aReview of the Environmental Protection Agency's draft IRIS assessment of tetrachloroethylene /$fCommittee to Review EPA's Toxicological Assessment of Tetrachloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$d2010 215 $a1 online resource (185 p.) 300 $aDescription based upon print version of record. 311 $a0-309-15094-9 320 $aIncludes bibliographical references. 327 $a""Front Matter""; ""Preface""; ""Abbreviations""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Overview of the Toxicokinetics of Tetrachloroethylene""; ""3 Neurotoxicity""; ""4 Reproductive and Developmental Effects""; ""5 Genotoxicity""; ""6 Hepatic Toxicity and Cancer""; ""7 Renal Toxicity and Cancer""; ""8 Hematopoietic Effects""; ""9 General Review of Epidemiologic Evidence Pertaining to Cancer""; ""10 Reference Values for Tetrachloroethylene""; ""11 Cancer Risk Estimates for Tetrachloroethylene""; ""12 Moving Beyond the Current State of Practice""; ""References"" 327 $a""Appendix A: Biographic Information on the Committee on Tetrachloroethylene""""Appendix B: Dissenting Statement and Rebuttal"" 330 $a"Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure"--Publisher's description. 606 $aTetrachloroethylene$xToxicology 606 $aTetrachloroethylene$xRisk assessment 615 0$aTetrachloroethylene$xToxicology. 615 0$aTetrachloroethylene$xRisk assessment. 676 $a615.9512 712 02$aNational Academies Press (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910807236103321 996 $aReview of the Environmental Protection Agency's draft IRIS assessment of tetrachloroethylene$94124162 997 $aUNINA