LEADER 05489nam 2200697 450 001 9910807131103321 005 20200520144314.0 010 $a1-118-79439-7 010 $a1-118-79420-6 010 $a1-118-79437-0 035 $a(CKB)3710000000128998 035 $a(EBL)1712885 035 $a(SSID)ssj0001227657 035 $a(PQKBManifestationID)11993708 035 $a(PQKBTitleCode)TC0001227657 035 $a(PQKBWorkID)11280395 035 $a(PQKB)11050260 035 $a(OCoLC)881571458 035 $a(MiAaPQ)EBC1712885 035 $a(DLC) 2014001126 035 $a(Au-PeEL)EBL1712885 035 $a(CaPaEBR)ebr10885018 035 $a(CaONFJC)MIL620542 035 $a(PPN)224932446 035 $a(EXLCZ)993710000000128998 100 $a20140702h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMucoadhesive materials and drug delivery systems /$fedited by Vitaliy V. Khutoryanskiy ; Michelle Armstrong [and thirty-one others], contributors 210 1$aChichester, [England] :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (352 p.) 300 $aIncludes index. 311 $a1-119-94143-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aMucoadhesive Materials and Drug Delivery Systems; Contents; About the Editor; List of Contributors; Preface; Section One: Structure and Physiology of Mucosal Surfaces in Relation to Drug Delivery; 1 Oral Mucosa: Physiological and Physicochemical Aspects; 1.1 Anatomical and Histological Aspects of Oral Cavity Tissues; 1.1.1 Tissue Architecture; 1.1.2 Innervation; 1.1.3 Receptors; 1.2 Production and Composition of Saliva; 1.2.1 Major Salivary Glands; 1.2.2 Minor Salivary Glands; 1.2.3 Saliva Composition; 1.2.4 Mucins; 1.2.5 Proline-rich Proteins; 1.2.6 Statherins; 1.2.7 Cystatins 327 $a1.2.8 Histatins1.2.9 Salivary Amylase; 1.2.10 Diversity of Salivary Film; 1.3 Surface Architecture, Mechanical, Rheological and Transport Properties of Salivary Pellicle; 1.3.1 Ex Vivo Pellicle; 1.3.2 Saliva Collection and Handling; 1.3.3 Rheology; 1.3.4 Interfacial Rheology; 1.3.5 Adsorption and Surface Architecture; 1.3.6 Surface Forces; 1.3.7 Lubrication; 1.3.8 Transport Properties; 1.4 Future Perspective; References; 2 Anatomy of the Eye and the Role of Ocular Mucosa in Drug Delivery; 2.1 Introduction; 2.2 Anatomy of the Eye; 2.2.1 Outer Membranes; Conjunctiva, Cornea and Sclera 327 $a2.2.2 Aqueous Chamber, Lens and Vitreous Body2.2.3 Choroid and Retina; 2.3 Introduction to Ocular Mucosa; 2.4 The Role of Ocular Mucosa in Drug Delivery; 2.5 Models for Ocular Drug Delivery; 2.6 Recent Advances in Topical Ocular Drug Delivery; 2.6.1 Improving Corneal Retention; 2.6.2 Other Topical Drug Delivery Options; 2.7 Conclusions; References; 3 Drug Delivery Across the Nasal Mucosa; 3.1 Introduction; 3.2 Drug Delivery via the Nasal Mucosa; 3.2.1 Drugs Administered for Local Action; 3.2.2 Drugs Administered for Systemic Effect; 3.2.3 Peptide and Protein Delivery 327 $a3.3 Anatomy and Physiology of the Nasal Cavity3.3.1 Structure and Function of the Nasal Cavity; 3.3.2 Nasal Epithelia; 3.3.3 Airflow; 3.3.4 Nasal Secretions; 3.3.5 Mucociliary Clearance; 3.4 Disease States of the Nasal Cavity; 3.4.1 Disease States Altering Drug Absorption; 3.5 Transport Across the Membrane; 3.5.1 Transport Across the Nasal Membrane; 3.5.2 The Solute Carrier Family; 3.5.3 Other Nasal Mucosa Transporters; 3.5.4 Efflux; 3.5.5 Paracellular Transport; 3.6 Nose-to-Brain Drug Delivery; 3.7 Conclusion; References; 4 Gastrointestinal Mucosa and Mucus; 4.1 Introduction 327 $a4.1.1 General Gastrointestinal Physiology4.2 The Gastrointestinal Mucus; 4.2.1 What is Mucus?; 4.2.2 Mucus Composition; 4.2.3 Anatomy of Goblet Cells and Mucin Biosynthesis; 4.2.4 Regulation of Mucus Secretion; 4.2.5 Mucus Functions; 4.2.6 Mucus Layer Structure: The Double-Layer Architecture; 4.2.7 Mucus Thickness; 4.2.8 Mucus Rheology; 4.2.9 Mucus Turnover; 4.2.10 Mucus and Ageing; 4.2.11 Mucus and Gastrointestinal Disease; 4.3 Conclusions; References; 5 Vaginal Mucosa and Drug Delivery; 5.1 Introduction; 5.2 Drug Delivery and the Human Vagina 327 $a5.2.1 Anatomical and Physiological Considerations 330 $aMucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms 606 $aBioadhesive drug delivery systems 606 $aDrug delivery systems 606 $aMucous membrane 615 0$aBioadhesive drug delivery systems. 615 0$aDrug delivery systems. 615 0$aMucous membrane. 676 $a615.1 702 $aKhutoryanskiy$b Vitaliy V. 702 $aArmstrong$b Michelle 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910807131103321 996 $aMucoadhesive materials and drug delivery systems$93988968 997 $aUNINA