LEADER 05336nam 22007334a 450 001 9910807054603321 005 20200520144314.0 010 $a1-281-23753-1 010 $a9786611237530 010 $a0-470-26226-5 010 $a0-470-26225-7 035 $a(CKB)1000000000414492 035 $a(EBL)333803 035 $a(OCoLC)476138578 035 $a(SSID)ssj0000238798 035 $a(PQKBManifestationID)11924912 035 $a(PQKBTitleCode)TC0000238798 035 $a(PQKBWorkID)10234078 035 $a(PQKB)10017941 035 $a(MiAaPQ)EBC333803 035 $a(Au-PeEL)EBL333803 035 $a(CaPaEBR)ebr10226724 035 $a(CaONFJC)MIL123753 035 $a(PPN)194582698 035 $a(OCoLC)173469796 035 $a(FINmELB)ELB177439 035 $a(EXLCZ)991000000000414492 100 $a20070924d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRNA and DNA editing $emolecular mechanisms and their integration into biological systems /$fedited by Harold C. Smith 205 $a1st ed. 210 $aHoboken, N.J. $cWiley-Interscience$dc2008 215 $a1 online resource (464 p.) 300 $aDescription based upon print version of record. 311 $a0-470-10991-2 320 $aIncludes bibliographical references and index. 327 $aRNA AND DNA EDITING; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I DIVERSIFICATION OF THE PROTEOME THROUGH RNA AND DNA EDITING; CHAPTER 1 DIVERSIFYING EXON CODE THROUGH A-TO-I RNA EDITING; 1.1 Introduction and Background; 1.1.1 Initial Discovery and Context of A-to-I RNA Editing and ADARs; 1.1.2 Important Cases of Recoding by A-to-I Modification in Pre-mRNA; 1.1.3 Cis-Acting Features for A-to-I Editing; 1.1.4 Properties of the A-to-I Editing Machinery; 1.2 Main Questions in the Field and Approaches; 1.2.1 Biochemical Versus Computational Approaches; 1.2.2 Editing of miRNA Sequences 327 $a1.3 Future Directions: Evolution of Editing Sites and MachineryReferences; CHAPTER 2 ANTIBODY GENE DIVERSIFICATION BY AID-CATALYZED DNA EDITING; 2.1 Introduction; 2.2 Before AID; 2.2.1 Without DNA (Darkness) and with DNA (Light); 2.2.2 Prominent Early Models for Antibody Diversification; 2.2.3 How Protein Sequencing Technology Enabled an Understanding of Antibody Diversity; 2.2.4 Somatic DNA Rearrangements Underpin V(D)J Joining and Create the Primary Antibody Repertoire; 2.2.5 Additional Antibody Diversity by Somatic Hypermutation (and Gene Conversion in Some Animals) 327 $a2.2.6 Altering Antibody Function by Class Switch Recombination (Isotype Switching)2.3 After AID; 2.3.1 A Novel Deaminase Is Required for CSR, SHM, and IGC; 2.3.2 AID Is a DNA Cytosine Deaminase that Directly Triggers Antibody Diversification; 2.3.3 The Importance of Uracil Bases in DNA In Vivo; 2.3.4 Processing of AID-induced Lesions: The Molecular Mechanism of Somatic-Hypermutation; 2.3.5 Processing of AID-induced Lesions: The Molecular Mechanism of Immunoglobulin Gene Conversion; 2.3.6 Processing of AID-induced Lesions: The Molecular Mechanism of Class Switch Recombination 327 $a2.4 Hot Areas and Speculations2.4.1 Immunodeficiency Syndromes Caused by Defects in AID-Mediated Ig Gene Diversification; 2.4.2 Regulating the DNA Mutator Activity of AID; 2.4.3 Misregulation of AID and Cancer; 2.4.4 AID Is But One Member of a Much Larger Family of Polynucleotide Deaminases; 2.5 Conclusions; Acknowledgments; References; CHAPTER 3 PROTEIN-PROTEIN AND RNA-PROTEIN INTERACTIONS IN U-INSERTION/DELETION RNA EDITING COMPLEXES; 3.1 A Bizarre Phenomenon and its Raison D'e?tre; 3.2 The Catalytic Mechanism and Machinery 327 $a3.3 Extent of U-Insertion/Deletion RNA Editing in Trypanosoma and Leishmania Species3.4 Functional Studies of Editing Complex Subunits; 3.4.1 REN1, REN2, and MP67. Endonuclease Homologs; 3.4.2 REX1 and REX2. Exonuclease Homologs; 3.4.3 RET2. TUTase; 3.4.4 REL1 and REL2. Ligase Homologs; 3.4.5 MP81, MP63, MP42, MP46, MP44, MP24, MP18. Structural Components; 3.5 RNA-Protein Interactions: Isolated Subunits and Assembled Editing Complexes; 3.5.1 MP42; 3.5.2 MP24; 3.5.3 RNA-Protein Interactions in Assembled Editing Complexes; 3.6 Concluding Remarks; Acknowledgments; References 327 $aCHAPTER 4 MACHINERY OF RNA EDITING IN PLANT ORGANELLES 330 $aRNA and DNA Editing assembles a team of leading experts who present the latest discoveries in the field alongside the latest models and methodology. In addition, the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes. 606 $aRNA editing 606 $aDNA 606 $aNucleotide sequence 606 $aGenetic transcription 615 0$aRNA editing. 615 0$aDNA. 615 0$aNucleotide sequence. 615 0$aGenetic transcription. 676 $a572.8/8 701 $aSmith$b Harold C$0168662 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910807054603321 996 $aRNA and DNA editing$94044690 997 $aUNINA