LEADER 05493nam 2200745 a 450 001 9910806300303321 005 20200520144314.0 010 $a9786612342936 010 $a9781282342934 010 $a1282342932 010 $a9780470727010 010 $a0470727012 010 $a9780470727003 010 $a0470727004 035 $a(CKB)1000000000687516 035 $a(EBL)470691 035 $a(OCoLC)609849707 035 $a(SSID)ssj0000307383 035 $a(PQKBManifestationID)11225257 035 $a(PQKBTitleCode)TC0000307383 035 $a(PQKBWorkID)10244605 035 $a(PQKB)10743465 035 $a(MiAaPQ)EBC470691 035 $a(Au-PeEL)EBL470691 035 $a(CaPaEBR)ebr10301036 035 $a(CaONFJC)MIL234293 035 $a(PPN)199220557 035 $a(Perlego)2785594 035 $a(EXLCZ)991000000000687516 100 $a20080125d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe pulmonary epithelium in health and disease /$fedited by David Proud 205 $a1st ed. 210 $aChichester, England ;$aHoboken, NJ $cJohn Wiley & Sons$dc2008 215 $a1 online resource (461 p.) 300 $aDescription based upon print version of record. 311 08$a9780470059517 311 08$a0470059516 320 $aIncludes bibliographical references and index. 327 $aThe Pulmonary Epithelium in Health and Disease; Contents; Preface; List of Contributors; 1 Pulmonary Epithelium: Cell Types and Functions; 1.1 Introduction; 1.2 Epithelial cell types and functions in the cartilaginous proximal airway region; 1.3 Epithelial cell types and functions of the non-cartilaginous distal bronchioles; 1.4 Epithelial cell types and functions of the gas exchange region; 1.5 Circulating stem cells and applications in lung regenerative medicine; 1.6 Stem cell therapy: embryonic or adult?; 1.7 Conclusion; 2 Epithelial Adhesive Structures and Adhesion Molecule Expression 327 $a2.1 Introduction2.2 Cell-cell adhesive structures; 2.3 Cell-substratum adhesion; 2.4 Conclusion; 3 The Epithelium as a Target; 3.1 Introduction; 3.2 Asthma; 3.3 Alteration in epithelial cell type distribution; 3.4 Overview of epithelial damage in asthma; 3.5 Chronic obstructive pulmonary disease; 3.6 Effect of cigarette smoke; 3.7 Other causative factors; 3.8 Alveolar epithelial cell apoptosis - emphysema; 3.9 Overview of epithelial damage in COPD; 3.10 Damage to the epithelium in other diseases; 3.11 Conclusions; 4 Epithelial Repair and Function 327 $a4.1 Brief introduction to epithelial shedding-repair and associated functions in health and disease4.2 Repair following shedding of single columnar epithelial cells and following shedding of clusters of columnar cells; 4.3 Epithelial denudation; 4.4 Pharmacology of epithelial repair; 4.5 Epithelial shedding-restitution as a causative process in airway inflammation and remodelling; 5 Integration of Epithelial Ion Transport Activities into Airway Surface Liquid Volume and Ion Composition Regulation; 5.1 Introduction: the role of fluid in airway/ alveolar physiology 327 $a5.2 Model of ion and solute transport through airway epithelia5.3 Airway histology; 5.4 Airway ion secretion; 5.5 The cystic fibrosis transmembrane conductance regulator; 5.6 Calcium-activated chloride channels; 5.7 K+ channels; 5.8 Airway ion absorption; 5.9 Measurement of ion and water transport in airway epithelia; 5.10 In vivo transepithelial PDs; 5.11 Volume flow measurements; 5.12 Physiologically 'thin film' measurements of ASL volume regulation with confocal microscopy and microelectrodes: studies of normal and CF airway epithelia 327 $a5.13 The role of physiologic airway shear-stress in ion transport and ASL regulation5.14 Fluid transport across the alveolar epithelium; 6 Structure and Function of Cilia; 6.1 Introduction; 6.2 Structure; 6.3 Function; 6.4 Ciliary dysfunction associated with disease; 7 Composition and Function of Airway Mucus; 7.1 Airway 'mucus'; 7.2 Respiratory tract mucins; 7.3 Mucin genes and gene products; 7.4 MUC5AC; 7.5 MUC5B; 7.6 Airway mucus hypersecretory phenotype in COPD; 7.7 Airway mucus hypersecretory phenotype in asthma; 7.8 Mucociliary clearance in asthma and COPD 327 $a7.9 Mechanisms of airway goblet cell hyperplasia 330 $a""This is essential reading for everyone who would like to update their knowledge of the pulmonary epithelium. It offers a comparison between laboratory animal models and human lungs, highlighting the differences and the similarities between the two, which will be particularly useful to researchers."" -Doody's, April 2009 The past two decades have seen extraordinary advances in our understanding of the role of the pulmonary epithelium in airway health and disease. Our understanding of epithelial biology has expanded exponentially in the past decade. This book provides a unique 606 $aRespiratory organs$xPathophysiology 606 $aPulmonary endothelium 606 $aEpithelium 615 0$aRespiratory organs$xPathophysiology. 615 0$aPulmonary endothelium. 615 0$aEpithelium. 676 $a616.2 701 $aProud$b David$01677963 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806300303321 996 $aThe pulmonary epithelium in health and disease$94045257 997 $aUNINA