LEADER 04973nam 22007695 450 001 9910806198603321 005 20240312144349.0 010 $a3-031-30023-8 024 7 $a10.1007/978-3-031-30023-3 035 $a(PPN)27543219X 035 $a(CKB)30119387000041 035 $a(DE-He213)978-3-031-30023-3 035 $a(MiAaPQ)EBC31095553 035 $a(Au-PeEL)EBL31095553 035 $a(EXLCZ)9930119387000041 100 $a20240129d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPharmaceutical Biotechnology$b[electronic resource] $eFundamentals and Applications /$fedited by Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm 205 $a6th ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (XXV, 682 p. 259 illus., 245 illus. in color.) 311 08$a9783031300226 327 $aMolecular Biotechnology -- Biophysical and biochemical analysis of recombinant proteins -- Production and downstream processing of biotech products -- Formulation of biotech products, including biopharmaceutical considerations -- Pharmacokinetics and pharmacodynamics of peptide and protein drugs -- Immunogenicity of pharmaceutical proteins -- General considerations of monoclonal antibodies from structure to therapeutic application -- Genomics, Other ?Omics? Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques -- Dispensing biotechnology products: handling, professional education and product information -- Economic considerations in medical biotechnology -- Regulatory framework for biosimilars -- Vaccines -- Oligonucleotides and siRNA -- Gene therapy -- Stem cell technology -- Therapeutic Applications.-Endocrinology -- Insulin -- Follicle-stimulating hormone -- Growth hormone -- Cardiovascular and Respiratory Applications -- Recombinant coagulation factors and thrombolytics -- Recombinant human deoxyribonuclease -- Oncology -- Monoclonal antibodies in oncology -- Hematopoetic growth factors -- Inflammation and Immunemodulation -- Monoclonal antibodies in transplantation -- Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy -- Interferons and interleukins -- Anti-infectious diseases -- Monoclonal antibodies -- Enzyme replacement therapy. 330 $aThis introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology. 606 $aPharmaceutical chemistry 606 $aBiotechnology 606 $aPharmacology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aDrug delivery systems 606 $aBiologicals 606 $aBiopharmaceutics 606 $aPharmaceutics 606 $aBiotechnology 606 $aPharmacology 606 $aBiomedical Research 606 $aDrug Delivery 606 $aBiologics 615 0$aPharmaceutical chemistry. 615 0$aBiotechnology. 615 0$aPharmacology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aDrug delivery systems. 615 0$aBiologicals. 615 0$aBiopharmaceutics. 615 14$aPharmaceutics. 615 24$aBiotechnology. 615 24$aPharmacology. 615 24$aBiomedical Research. 615 24$aDrug Delivery. 615 24$aBiologics. 676 $a615.19 702 $aCrommelin$b Daan J. A$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSindelar$b Robert D$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMeibohm$b Bernd$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806198603321 996 $aPharmaceutical biotechnology$957094 997 $aUNINA