LEADER 04147nam 2200733 a 450 001 9910806162503321 005 20240516065051.0 010 $a9786613694461 010 $a9781280784071 010 $a1280784075 010 $a9780470720738 010 $a0470720735 010 $a9780470718421 010 $a0470718420 035 $a(CKB)1000000000688145 035 $a(EBL)703912 035 $a(OCoLC)797918492 035 $a(SSID)ssj0000715489 035 $a(PQKBManifestationID)11435131 035 $a(PQKBTitleCode)TC0000715489 035 $a(PQKBWorkID)10701713 035 $a(PQKB)11341815 035 $a(MiAaPQ)EBC703912 035 $a(Au-PeEL)EBL703912 035 $a(CaPaEBR)ebr10575664 035 $a(CaONFJC)MIL369446 035 $a(Perlego)2776629 035 $a(EXLCZ)991000000000688145 100 $a19831122d1982 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSubstance P in the nervous system 205 $a1st ed. 210 $aLondon $cPitman ;$aSummit, N.J., USA $cDistributed in North America by Ciba Pharmaceutical Co., Medical Education Administration$d1982 215 $a1 online resource (362 p.) 225 1 $aCiba Foundation symposium ;$v91 300 $a"Editors: Ruth Porter (organizer) and Maeve O'Connor"--P. v. 311 08$a9780470664087 311 08$a0470664088 311 08$a9780272796559 311 08$a0272796557 320 $aIncludes bibliographical references and indexes. 327 $aSubstance P in the nervous system; Contents; Introduction; Chemical neurotransmission-yesterday and today; Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia; Discussion; Substance P in peripheral sensory processes; Discussion; Localization of substance P in neuronal pathways; Discussion; Distribution of substance P in brain and periphery and its possible role as a co-transmitter; Discussion; Regulation of substance P expression and metabolism in vivo and in vitro; Discussion; GENERAL DISCUSSION; Coexistence of transmitters 327 $aSubstance P in nerve tissue in the gut Discussion; Biosynthesis, axonal transport and turnover of neuronal substance P; Discussion; Enzymic inactivation of substance P in the central nervous system; Discussion; Substance P receptors in the nervous system and possible receptor subtypes; Discussion; Relation of substance P to pain transmission: neurophysiological evidence; Discussion; Substance P in nociceptive sensory neurons; Discussion; If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function?; Discussion 327 $aModulation of cholinergic transmission by substance PDiscussion; The striatonigral substance P pathway and dopaminergic mechanisms; Discussion; Relation of substance P to stress and catecholamine metabolism; Discussion; Behavioural effects of substance P through dopaminergic pathways in the brain; Discussion; FINAL GENERAL DISCUSSION; Substance P antagonists; tumour cell lines and substance P; substance P and other tachykinins; substance P and clinical pain syndromes; substance P and neuronal systems; Index of contributors; Subject index 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium ;$v91. 606 $aSubstance P$vCongresses 606 $aNeurology$vCongresses 615 0$aSubstance P 615 0$aNeurology 676 $a599/.0188 701 $aPorter$b Ruth$064811 701 $aO'Connor$b Maeve$0284912 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806162503321 996 $aSubstance P in the nervous system$91963079 997 $aUNINA