LEADER 03575nam 2200649 a 450 001 9910806162503321 005 20240516065051.0 010 $a1-280-78407-5 010 $a9786613694461 010 $a0-470-72073-5 010 $a0-470-71842-0 035 $a(CKB)1000000000688145 035 $a(EBL)703912 035 $a(OCoLC)797918492 035 $a(SSID)ssj0000715489 035 $a(PQKBManifestationID)11435131 035 $a(PQKBTitleCode)TC0000715489 035 $a(PQKBWorkID)10701713 035 $a(PQKB)11341815 035 $a(MiAaPQ)EBC703912 035 $a(Au-PeEL)EBL703912 035 $a(CaPaEBR)ebr10575664 035 $a(CaONFJC)MIL369446 035 $a(EXLCZ)991000000000688145 100 $a19831122d1982 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSubstance P in the nervous system 205 $a1st ed. 210 $aLondon $cPitman ;$aSummit, N.J., USA $cDistributed in North America by Ciba Pharmaceutical Co., Medical Education Administration$d1982 215 $a1 online resource (362 p.) 225 1 $aCiba Foundation symposium ;$v91 300 $a"Editors: Ruth Porter (organizer) and Maeve O'Connor"--P. v. 311 $a0-470-66408-8 311 $a0-272-79655-7 320 $aIncludes bibliographical references and indexes. 327 $aSubstance P in the nervous system; Contents; Introduction; Chemical neurotransmission-yesterday and today; Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia; Discussion; Substance P in peripheral sensory processes; Discussion; Localization of substance P in neuronal pathways; Discussion; Distribution of substance P in brain and periphery and its possible role as a co-transmitter; Discussion; Regulation of substance P expression and metabolism in vivo and in vitro; Discussion; GENERAL DISCUSSION; Coexistence of transmitters 327 $aSubstance P in nerve tissue in the gut Discussion; Biosynthesis, axonal transport and turnover of neuronal substance P; Discussion; Enzymic inactivation of substance P in the central nervous system; Discussion; Substance P receptors in the nervous system and possible receptor subtypes; Discussion; Relation of substance P to pain transmission: neurophysiological evidence; Discussion; Substance P in nociceptive sensory neurons; Discussion; If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function?; Discussion 327 $aModulation of cholinergic transmission by substance PDiscussion; The striatonigral substance P pathway and dopaminergic mechanisms; Discussion; Relation of substance P to stress and catecholamine metabolism; Discussion; Behavioural effects of substance P through dopaminergic pathways in the brain; Discussion; FINAL GENERAL DISCUSSION; Substance P antagonists; tumour cell lines and substance P; substance P and other tachykinins; substance P and clinical pain syndromes; substance P and neuronal systems; Index of contributors; Subject index 410 0$aCiba Foundation symposium ;$v91. 606 $aSubstance P$vCongresses 606 $aNeurology$vCongresses 615 0$aSubstance P 615 0$aNeurology 676 $a599/.0188 701 $aPorter$b Ruth$064811 701 $aO'Connor$b Maeve$0284912 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806162503321 996 $aSubstance P in the nervous system$91963079 997 $aUNINA