LEADER 04966nam 22006375 450 001 9910805569403321 005 20240117162659.0 010 $a9783031473319 010 $a3031473310 024 7 $a10.1007/978-3-031-47331-9 035 $a(MiAaPQ)EBC31072018 035 $a(Au-PeEL)EBL31072018 035 $a(DE-He213)978-3-031-47331-9 035 $a(OCoLC)1419055465 035 $a(CKB)29958304700041 035 $a(EXLCZ)9929958304700041 100 $a20240117d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHelicobacter pylori and Gastric Cancer /$fedited by Steffen Backert 205 $a1st ed. 2023. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2023. 215 $a1 online resource (328 pages) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v444 311 08$aPrint version: Backert, Steffen Helicobacter Pylori and Gastric Cancer Cham : Springer International Publishing AG,c2024 9783031473302 327 $aGastric stem cell biology and Helicobacter pylori infection -- Clinical pathogenesis and molecular mechanisms of gastric cancerogenesis -- Helicobacter pylori metabolism and mitochondrial dysfunction in gastric cancer development -- Immune biology and persistence of Helicobacter pylori in gastric diseases -- Pathogenomics of Helicobacter pylori infection -- Helicobacter pylori interactions with the microbiota and gastric cancer development -- Helicobacter pylori-induced host cell DNA damage and gastric carcinogenesis -- Gastric inflammation and oncogenic signal transduction networks by Helicobacter pylori -- Impact of Helicobacter pylori oncoprotein CagA and vacuolating cytotoxin VacA in gastric cancer -- Role of proteases in Helicobacter pylori infections and gastric diseases -- Clinical management of gastric cancer treatment regimes. 330 $aThis volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed. Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world?s population. H. pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by this bacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H. pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H. pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H. pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented. This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v444 606 $aMedical microbiology 606 $aCancer 606 $aBacteria 606 $aDiseases$xCauses and theories of causation 606 $aMedical Microbiology 606 $aCancer Biology 606 $aBacteria 606 $aPathogenesis 615 0$aMedical microbiology. 615 0$aCancer. 615 0$aBacteria. 615 0$aDiseases$xCauses and theories of causation. 615 14$aMedical Microbiology. 615 24$aCancer Biology. 615 24$aBacteria. 615 24$aPathogenesis. 676 $a616.9041 700 $aBackert$b Steffen$01588919 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910805569403321 996 $aHelicobacter pylori and Gastric Cancer$93883193 997 $aUNINA