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100   $a20150209d2014      uy             0
101 0 $aeng
135   $aur|n|||||||||
181   $ctxt
182   $cc
183   $acr
200 10$aHuman Longevity
210   $cCRC Press$d2014
215   $a1 online resource (248 p.)
300   $aDescription based upon print version of record.
311   $a1-322-63399-1 
311   $a1-4665-9486-1 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aChapter 5: Remarkable Longevity of Queens of Social Insects Likely Involves Dietary Manipulation to Minimize Levels of Polyunsaturates and Decrease Membrane PeroxidationChapter 6: Membrane Peroxidation Hypothesis Helps Explain Longevity in Birds, Rodents, and Whales; Chapter 7: Did Longevity Help Humans Become Super Humans?; Chapter 8: Mitochondrial Diseases and Aging Have Much in Common; Chapter 9: Revised Mitochondrial Hypothesis of Aging Highlights Energy Deficiency Caused by Errors of Replication (Mutations) of mtDNA; Chapter 10: Benefits of Polyunsaturated Mitochondrial Membranes
327   $aChapter 16: Uncoupling Proteins (UCPs) of Mitochondria Purposely Waste Energy to Prevent Membrane DamageChapter 17: Mitochondrial Fission Protects against Oxidative Stress by Minting a Continuous Supply of Cardiolipin and Other Polyunsaturated Phospholipids; Chapter 18: Mitophagy Eliminates Toxic Mitochondria; Chapter 19: Longevity Genes Likely Protect Membranes; Chapter 20: Aging as a Cardiolipin Disease That Can Be Treated; Back Cover
330   $aMore than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membran
606   $aAging$xGenetic aspects
606   $aMitochondria
606   $aOxidative stress
606   $aOmega-3 fatty acids$xHealth aspects
615  0$aAging$xGenetic aspects.
615  0$aMitochondria.
615  0$aOxidative stress.
615  0$aOmega-3 fatty acids$xHealth aspects.
676   $a612.6/7
686   $aMED008000$aSCI049000$aTEC012000$2bisacsh
700   $aValentine$b Raymond C$0107115
701   $aValentine$b David L$01587203
801  0$bOCoLC-P
801  1$bOCoLC-P
906   $aBOOK
912   $a9910800188203321
996   $aHuman Longevity$93874670
997   $aUNINA