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010   $a981-9974-71-2
024 7 $a10.1007/978-981-99-7471-9
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035   $a(DE-He213)978-981-99-7471-9
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100   $a20240117d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aHematopoietic Stem Cells $eKeystone of Tissue Development and Regenerative Medicine /$fedited by Meng Zhao, Pengxu Qian
205   $a1st ed. 2023.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023.
215   $a1 online resource (218 pages)
225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1442
311 08$aPrint version: Zhao, Meng Hematopoietic Stem Cells Singapore : Springer Singapore Pte. Limited,c2024 9789819974702 
320   $aIncludes bibliographical references.
327   $aChapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells.
330   $aThis book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.
410  0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1442
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aStem cells
606   $aDevelopmental biology
606   $aBiomedical Research
606   $aStem Cell Biology
606   $aDevelopmental Biology and Stem Cells
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aStem cells.
615  0$aDevelopmental biology.
615 14$aBiomedical Research.
615 24$aStem Cell Biology.
615 24$aDevelopmental Biology and Stem Cells.
676   $a612.4/1
702   $aZhao$b Meng
702   $aQian$b Pengxu
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910800113103321
996   $aHematopoietic Stem Cells$94311349
997   $aUNINA