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010   $a9786613274465
010   $a1-4398-1994-7
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100   $a20180331d2011      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aHandbook of analysis of oligonucleotides and related products /$fedited by Jose V. Bonilla, G. Susan Srivatsa
210  1$aBoca Raton, Fla. :$cCRC Press,$d2011.
215   $a1 online resource (502 p.)
300   $aDescription based upon print version of record.
311   $a1-4398-1993-9 
320   $aIncludes bibliographical references and index.
327   $aFront Cover; Contents; Preface; Editors; Contributors; Introduction; Chapter 1: Purity Analysis and Impurities Determination by Reversed-Phase High-Performance Liquid Chromatography; Chapter 2: Purity Analysis and Impurities Determination by AEX-HPLC; Chapter 3: Purity Analysis and Molecular Weight Determination by Size Exclusion HPLC; Chapter 4: Analysis of Oligonucleotides by Liquid Chromatography and Mass Spectrometry; Chapter 6: Tm Analysis of Oligonucleotides; Chapter 7: Purity and Content Analysis of Oligonucleotides by Capillary Gel Electrophoresis
327   $aChapter 8: Bioanalysis of Therapeutic Oligonucleotides Using Hybridization-Based Immunoassay TechniquesChapter 9: Oligonucleotide Assay and Potency; Chapter 10: Microbial Analysis : Endotoxin Testing; Chapter 11: Analysis of Residual Solvents by Head Space Gas Chromatography; Chapter 12: Determination of Extinction Coefficient; Chapter 13: Structural Determination by NMR; Chapter 14: Infrared Analysis of Oligonucleotides; Chapter 15: Stability Indicating Methods for Oligonucleotide Products; Chapter 16: Analysis by Hydrophilic Interaction Chromatography
327   $aChapter 17: Determination of Base CompositionChapter 19: Regulatory Considerations for the Development of Oligonucleotide Therapeutics; Back Cover
330   $aOligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the 
606   $aOligonucleotides$xAnalysis
606   $aBiochemistry
615  0$aOligonucleotides$xAnalysis.
615  0$aBiochemistry.
676   $a572.8/5
701   $aBonilla$b Jose V$01587831
701   $aSrivatsa$b Susan$01587832
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910800078703321
996   $aHandbook of analysis of oligonucleotides and related products$93876397
997   $aUNINA