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010   $a3-031-42859-5
024 7 $a10.1007/978-3-031-42859-3
035   $a(CKB)29526938100041
035   $a(DE-He213)978-3-031-42859-3
035   $a(MiAaPQ)EBC31226240
035   $a(Au-PeEL)EBL31226240
035   $a(EXLCZ)9929526938100041
100   $a20240104d2024      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMacrolides as Immunomodulatory Agents /$fedited by Bruce K. Rubin, Masaharu Shinkai
205   $a1st ed. 2024.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024.
215   $a1 online resource (VIII, 287 p. 18 illus., 10 illus. in color.) 
225 1 $aProgress in Inflammation Research,$x2296-4525 ;$v92
311   $a3-031-42858-7 
320   $aIncludes bibliographical references.
327   $aPart I. Mechanisms of Action and Novel Macrolides -- Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity -- Macrolides and Inflammatory Cells, Signaling, and Mediators -- Part II. Clinical Use for Airway Disease -- Macrolides as Immunomodulatory Agents -- Macrolides and Cystic Fibrosis -- Non-CF Bronchiectasis -- Macrolide Use in Chronic Obstructive Pulmonary Disease -- Macrolides and Asthma Therapy -- Macrolides and Interstitial Lung Diseases -- Macrolides in Acute Respiratory Distress Syndrome and Acute Lung Injury -- Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis -- Macrolides for Rhinosinusitis and Nasal Polyps -- Part III. Clinical Use for Other Diseases -- Macrolides for Cancer -- Macrolides in Chronic Skin Disorders -- Macrolide Use in Preschool Aged Children with Acute or Recurrent Respiratory Tract Illnesses with Wheezing -- Macrolides and Immunomodulation: Today and the Future.
330   $aFor over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties.
410  0$aProgress in Inflammation Research,$x2296-4525 ;$v92
606   $aInflammation
606   $aCancer
606   $aImmune system
606   $aCellular signal transduction
606   $aImmunology
606   $aImmunotherapy
606   $aInflammation
606   $aCancer Biology
606   $aImmune Cell Signalling
606   $aImmunology
606   $aImmunotherapy
615  0$aInflammation.
615  0$aCancer.
615  0$aImmune system.
615  0$aCellular signal transduction.
615  0$aImmunology.
615  0$aImmunotherapy.
615 14$aInflammation.
615 24$aCancer Biology.
615 24$aImmune Cell Signalling.
615 24$aImmunology.
615 24$aImmunotherapy.
676   $a615.329
702   $aRubin$b Bruce K.
702   $aShinkai$b Masaharu
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910799201903321
996   $aMacrolides As Immunomodulatory Agents$93872850
997   $aUNINA