LEADER 05659nam 2200685 450 001 9910797589003321 005 20200520144314.0 010 $a0-12-803877-2 010 $a0-12-803876-4 035 $a(CKB)3710000000463840 035 $a(EBL)2189947 035 $a(SSID)ssj0001551748 035 $a(PQKBManifestationID)16169598 035 $a(PQKBTitleCode)TC0001551748 035 $a(PQKBWorkID)14812525 035 $a(PQKB)11521883 035 $a(MiAaPQ)EBC2189947 035 $a(Au-PeEL)EBL2189947 035 $a(CaPaEBR)ebr11091596 035 $a(CaONFJC)MIL823997 035 $a(OCoLC)928738451 035 $a(PPN)192172190 035 $a(EXLCZ)993710000000463840 100 $a20150901d2015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMechanism of the anticancer effect of phytochemicals /$fedited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA 205 $aFirst edition. 210 1$aWaltham, MA :$cElsevier Science,$d2015. 215 $a1 online resource (285 p.) 225 1 $aEnzymes,$x1874-6047 ;$vvolume 37 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references and indexes. 327 $aFront Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes 327 $a3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References 327 $aChapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetins? Effect on Apoptosis 327 $a2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetins? Role as an Anti-Inflammatory Agent; 2.8. Quercetins? Influence on p53; 2.9. Quercetins? Nontoxicity Against Normal Cells; 2.10. Quercetins? Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity 327 $a3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action 327 $aReferences 330 $aVolume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field 410 0$aEnzymes ;$vv. 37. 606 $aCancer$xChemoprevention 606 $aCancer$xDiet therapy 606 $aPhytochemicals$xTherapeutic use 615 0$aCancer$xChemoprevention. 615 0$aCancer$xDiet therapy. 615 0$aPhytochemicals$xTherapeutic use. 676 $a616.994061 702 $aBathaie$b S. Zahra 702 $aTamanoi$b Fuyuhiko 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797589003321 996 $aMechanism of the anticancer effect of phytochemicals$93742830 997 $aUNINA LEADER 01294nas 22004092c 450 001 9910894026203321 005 20260218112959.0 024 7 $aurn:nbn:de:bsz:16-diglit-298021 035 $a(CKB)5280000000202231 035 $a(DE-599)ZDB2861335-1 035 $a(DE-101)1105773175 035 $a(DE-599)2861335-1 035 $a(EXLCZ)995280000000202231 100 $a20160708a20169999 |y | 101 0 $ager 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aHeidelbergische Jahrbücher der Literatur$hAbtheilung 5$iPhilologie, Historie, schöne Literatur und Kunst 210 31$aHeidelberg$cUniversita?tsbibliothek Heidelberg$d2016- 215 $aOnline-Ressource 225 0 $aHeidelberger historische Besta?nde - digital 300 $aDigitalisierungsabsicht 300 $aReproduktion 517 1 $aHeidelbergische Jahrbu?cher der Literatur fu?r Philologie, Historie, scho?ne Literatur und Kunst 608 $aZeitschrift$2gnd-content 676 $a100 676 $a900 676 $a400 801 0$b0016 801 1$bDE-101 801 2$b0016 906 $aJOURNAL 912 $a9910894026203321 996 $aHeidelbergische Jahrbu?cher der Literatur$94232335 997 $aUNINA