LEADER 05083nam 2200541 450 001 9910797546903321 005 20200520144314.0 010 $a0-08-100006-5 035 $a(CKB)3710000000468287 035 $a(EBL)2197269 035 $a(Au-PeEL)EBL2197269 035 $a(CaPaEBR)ebr11306150 035 $a(CaONFJC)MIL826424 035 $a(OCoLC)929143587 035 $a(MiAaPQ)EBC2197269 035 $a(EXLCZ)993710000000468287 100 $a20161202h20162016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aInorganic controlled release technology $ematerials and concepts for advanced drug formulation /$fXiang Zhang, Mark Cresswell 210 1$aOxford, [England] ;$aWaltham, Massachusetts :$cButterworth-Heinemann,$d2016. 210 4$dİ2016 215 $a1 online resource (264 p.) 300 $aDescription based upon print version of record. 311 $a0-08-099991-3 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Inorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation; Copyright; Contents; About the Author; Preface; Acknowledgments; Key Features; Chapter 1: Materials for Inorganic Controlled Release Technology; 1.1. Introduction; 1.2. Comparison between Organic and Inorganic CRT; 1.3. Materials Chemistry and Processing Technology; 1.3.1. Fusion-Based Approach to Making Water-Soluble Glasses; 1.3.2. Sol-Gel Approach; 1.3.3. Surfactant Template Approach for Mesoporous Silica; 1.4. Materials Physics and Drug-Loaded Micro/Nanostructure; References 327 $aChapter 2: Materials Fundamentals of Drug Controlled Release2.1. Introduction of Materials Nanostructure; 2.1.1. The Structure of Amorphous Materials; 2.1.2. Theories of Amorphous Materials; 2.1.2.1. Glass Transition; 2.1.2.2. Free Volume Theory; 2.2. API Distribution Within Inorganic Matrices; 2.2.1. Traditional API Distribution; 2.2.2. API Distribution Within inorganic CRT Matrices; 2.3. Basic Understanding of Potential Molecular Interactions; 2.3.1. Classical API Excipients; 2.3.2. Interactions Between API and inorganic CRT Matrix Systems; 2.3.3. The Surface Chemistry of Silica 327 $a2.3.4. Molecular Interaction with Directionally Templated Mesoporous Silica Systems2.3.5. Towards Molecular Dispersion and Distribution; 2.3.6. Molecular Interaction Sites on Sol-Gel Silica and Phosphate Glass; 2.3.7. Dissolution of Phosphate Glass; 2.3.8. Glass Formulation for inorganic CRT; 2.4. Theory and Practical Modelling of Drug Controlled Release Kinetics; References; Further Reading; Chapter 3: Materials Characterization of Inorganic Controlled Release; 3.1. Introduction; 3.2. Chemical Analysis; 3.2.1. X-Ray Fluorescence; 3.2.1.1. Case Study: Contamination Investigation 327 $a3.2.2. Inductively Coupled Plasma Mass Spectrometry3.2.2.1. Case Study: Controlled Release of Strontium from P-glass; 3.2.2.2. Case Study: Detection of Cobalt and Chromium Ions in Patients with Metal-on-Metal Implants; 3.2.3. FTIR; 3.2.3.1. Case Study: FTIR Study of Silanol Groups in Silica, Slica-Alumina, and Zeolites; 3.2.3.2. Case Study: Quantification of Bridging and Non-bridging SiO as a Function of SiO2 % by FTIR; 3.2.4. X-Ray Photoelectron Spectroscopy (XPS)-Surface Chemistry 1; 3.2.4.1. Case Study: XPS Study on SiOSi Bridging Energy Variation 327 $a3.2.5. Secondary Ion Mass Spectrometry (SIMS)-Surface Chemistry 23.2.5.1. Case Study: Investigation of the Surface Chemistry of a Bioglass-Polymer Hybrid Composite; 3.3. Physical Property Analysis; 3.3.1. X-Ray Diffraction; 3.3.1.1. Case Study: Characterization of a Calcium Hydroxyapatite Reference Material5; 3.3.1.2. Case Study: Characterization of Amorphous and crystalline Materials; 3.3.2. Nanoporosity Characterization; 3.3.2.1. Case Study; 3.4. Microscopy; 3.4.1. SEM, BEM and EDX; 3.4.1.1. Case Study: drug-loaded sol-gel glass particles; 3.4.2. TEM 327 $a3.4.2.1. Case Study: drug-loaded mesoporous silica 330 $a Inorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation provides a practical guide to the use and applications of inorganic controlled release technology (iCRT) for drug delivery and other healthcare applications, focusing on newly developed inorganic materials such as bioresorbable glasses and bioceramics. The use of these materials is introduced for a wide range of applications that cover inorganic drug delivery systems for new drug development and the reformulation of existing drugs. The book describes basic concepts, principles, and industrial practic 606 $aControlled release technology 615 0$aControlled release technology. 676 $a664.024 700 $aZhang$b Xiang$0651555 702 $aCresswell$b Mark 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797546903321 996 $aInorganic controlled release technology$93835823 997 $aUNINA