LEADER 02898nam 2200637 450 001 9910797529903321 005 20230807193222.0 010 $a1-61147-825-1 035 $a(CKB)3710000000476329 035 $a(EBL)4086675 035 $a(SSID)ssj0001545583 035 $a(PQKBManifestationID)16135958 035 $a(PQKBTitleCode)TC0001545583 035 $a(PQKBWorkID)14340673 035 $a(PQKB)10114108 035 $a(MiAaPQ)EBC4086675 035 $a(EXLCZ)993710000000476329 100 $a20150202h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAt work in the early modern English theater $evaluing labor /$fMatthew Kendrick 210 1$aMadison :$cFairleigh Dickinson University Press,$d[2015] 210 4$d©2015 215 $a1 online resource (207 p.) 300 $aDescription based upon print version of record. 311 $a1-61147-826-X 311 $a1-61147-824-3 320 $aIncludes bibliographical references and index. 327 $aThe theater between craft and commodity -- Crafty performance in city comedy: Jonson's Every man in his humour and Chapman, Jonson, and Marston's Eastward ho! -- Casting apprentices in Beaumont's The knight of the burning pestle -- Thinking with the feet in Dekker's The shoemaker's holiday and Rowley's A shoemaker, a gentleman -- Labor and theatrical value on the shakespearean stage: a Midsummer night's dream and The tempest -- Afterword: performing laboring subjectivity. 330 $aThis book examines the drama of Shakespeare and his contemporaries from the perspective of the period's radically changing labor relations and the nascent emergence of the English working class. The book offers a new way to approach the period by situating drama at the intersection of early modern theater history and labor history. 606 $aEnglish drama$yEarly modern and Elizabethan, 1500-1600$xHistory and criticism 606 $aEnglish drama$y17th century$xHistory and criticism 606 $aTheater$zEngland$xHistory$y16th century 606 $aTheater$zEngland$xHistory$y17th century 606 $aLabor in literature 606 $aLabor movement$zEngland$xHistory$y16th century 606 $aLabor movement$zEngland$xHistory$y17th century 615 0$aEnglish drama$xHistory and criticism. 615 0$aEnglish drama$xHistory and criticism. 615 0$aTheater$xHistory 615 0$aTheater$xHistory 615 0$aLabor in literature. 615 0$aLabor movement$xHistory 615 0$aLabor movement$xHistory 676 $a822/.3093553 700 $aKendrick$b Matthew$f1982-$01480325 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797529903321 996 $aAt work in the early modern English theater$93696907 997 $aUNINA LEADER 13175nam 2200769 a 450 001 9910814767203321 005 20250718201835.0 010 $a9781118636831 010 $a111863683X 010 $a9781118636817 010 $a1118636813 010 $a9781118636848 010 $a1118636848 035 $a(CKB)2550000001111885 035 $a(EBL)1355719 035 $a(OCoLC)856870605 035 $a(SSID)ssj0000981429 035 $a(PQKBManifestationID)11590911 035 $a(PQKBTitleCode)TC0000981429 035 $a(PQKBWorkID)10971635 035 $a(PQKB)10782559 035 $a(MiAaPQ)EBC1355719 035 $a(Au-PeEL)EBL1355719 035 $a(CaPaEBR)ebr10748737 035 $a(CaONFJC)MIL511777 035 $a(PPN)194583767 035 $a(Perlego)1003517 035 $a(EXLCZ)992550000001111885 100 $a20130318d2013 uy 0 101 0 $aeng 135 $aur|n|---|||u| 181 $ctxt 182 $cc 183 $acr 200 00$aTextbook of influenza /$fedited by Robert G. Webster ... [et al.] 205 $a2nd ed. 210 $aChichester, West Sussex, U.K. $cWiley-Blackwell$d2013 215 $a1 online resource (522 pages) 300 $aDescription based upon print version of record. 311 08$aPrint version: Webster, Robert G. Textbook of Influenza. Hoboken : Wiley, ©2013 9780470670484 311 08$a9780470670484 311 08$a0470670487 311 08$a9781299805262 311 08$a1299805264 320 $aIncludes bibliographical references and index. 327 $aPART 1: Influenza: Perspective -- 1: Human influenza: One health, one world -- Introduction -- Global impact of influenza -- Influenza in a crowded, connected, and converging world -- Increasingly crowded -- Increasingly connected -- Convergence: poultry, pigs, people, and pandemics -- Global interconnectedness requires global coordination and response -- Global challenges for surveillance -- Global regulations for detection and control -- Global network for surveillance -- New opportunities in a changing world -- New tools for global detection and surveillance -- Instant and converging information -- Conclusions -- Acknowledgments -- References -- 2: Influenza pandemics: History and lessons learned -- Introduction -- Past and recent influenza pandemics -- The 1889 and 1918 pandemics -- The 1957 and 1968 pandemics -- Events in 1976 and 1977 -- The threat of an A (H5N1) pandemic -- Response to the H5N1 threat -- The 2009 H1N1 influenza pandemic -- Lessons learned from past influenza pandemics -- Zoonotic origins and unpredictability of pandemics -- Surveillance in swine was inadequate -- Antigenic and structural similarities are not predictors of severity -- An influenza pandemic can arise anywhere in the world -- Pandemic influenza can emerge in any season -- Initial retention of avian receptor binding characteristics in pandemic influenza viruses -- Vaccines to pandemic influenza viruses are not available during the first wave of infection -- Antivirals are the first line of defense -- Conclusions -- Acknowledgments -- References -- PART 2: Structure and replication -- 3: Structure, disassembly, assembly, and budding of influenza viruses -- Introduction -- Structure and virus morphology -- Structure. 327 $aVirus morphology -- Disassembly -- Fusion process -- Release of viral RNP -- Transport and assembly -- Budding -- Role of viral proteins -- Role of the eight RNP segments -- Role of host components -- Bud initiation -- Bud elongation and closure -- Conclusions -- Acknowledgments -- References -- 4: The virus genome and its replication -- The segmented RNA virus genome of influenza A and B viruses -- Viral mRNA synthesis (transcription) and viral RNA replication -- Regulation of viral RNA synthesis in infected cells -- The role of host factors in viral RNA synthesis -- Splicing and nuclear export of viral mRNAs -- Nuclear export of viral RNPs -- References -- 5: Influenza glycoproteins: Hemagglutinin and neuraminidase -- HA and NA structures, functions, antigenicity and classification: An overview -- Functions of hemagglutinin -- Receptor binding -- Receptor binding summary -- Hemagglutinin-mediated membrane fusion -- Membrane fusion summary -- Neuraminidase -- Inhibitors of HA and NA functions and potential antiviral drugs -- Receptor binding -- Membrane fusion -- Anti-NA drugs -- Prospects for additional targets for inhibition -- Antigenicity of HA and NA -- Structures of complexes formed by HA and NA with antibodies -- Infectivity neutralization -- Variation of HA and NA -- Effects of HA and NA glycosylation -- Cross-reactive anti-HA antibodies -- HA/NA co-variation of activity and specificity -- References -- 6: Proton channels of influenza A and B viruses -- Influenza A virus M2 protein -- The A/M2 protein has ion channel activity that is required for efficient viral replication -- M2 proton conduction mechanism -- Atomic structures of the A/M2 channel -- Inhibition of the A/M2 channel -- New development of A/M2 channel inhibitors -- Influenza B virus BM2 protein is also a proton channel 327 $a7: The NS1 protein: A master regulator of host and viral functions -- Introduction -- General features and structures of the influenza A virus NS1 protein -- Molecular and cellular functions -- Inhibition of the RIG-I pathway -- Inhibition of host gene expression -- Inhibition of the activity of two antiviral proteins: PKR and 2?-5?-oligoadenylate synthetase (OAS) -- Induction of the PI3 K by the NS1 protein -- Roles of the C-terminal motifs of the NS1 protein -- Other NS1 functions -- Unique function of the NS1 protein of influenza B virus (B/NS1): Binding IFN-induced ISG15 -- Regulation of the function of the NS1 protein of influenza A virus -- Impact of the NS1 protein of influenza A virus in virulence, host tropism, and immune responses -- NS1 protein as an antiviral target -- NS1-modified viruses as potential live attenuated vaccines -- Conclusions -- References -- 8: Structure and function of the influenza virus replication machinery and PB1-F2 -- Architecture of the vRNP -- Atomic structure of the influenza polymerase -- PA -- PB2 -- Role of PB1-F2 -- Composition and structure -- Functions -- Evolution and adaptation -- Perspectives -- Note added in proof -- Acknowledgments -- References -- 9: The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation -- The pandemic 1918 virus - an elusive killer virus is identified -- Virulence and pathogenicity of pandemic 1918 virus infections -- Host responses to infection with pandemic 1918 virus -- Bacterial coinfections in pandemic 1918 virus infections -- Viral determinants of pandemic 1918 virus pathogenicity -- Hemagglutinin (HA) -- Replication complex -- NS1 -- PB1-F2 -- NA -- Generation of vaccine viruses -- References -- 10: Pathogenesis -- Introduction -- Disease in mammalian and avian hosts -- Mammalian influenza -- Avian influenza. 327 $aAvian influenza virus infections in mammalian host -- Pathogenic mechanisms -- Tropism -- Spread of infection -- Virus load -- Escape of host defense -- Modulation of inflammatory response -- Synergism between influenza viruses and bacteria -- Hemagglutinin determines tropism and spread of infection -- Receptor specificity -- Fusion activation -- Pathogenicity is a multifactorial trait: receptor specificity, N-glycosylation and fusion activity of HA determine lung pathogenicity in mice -- Neuraminidase promotes virus release and destroys decoy receptors -- Polymerase determines replication rates -- NS1 modulates host responses -- Modulation of the IFN response -- Modulation of signaling cascades -- Modulation of apoptosis -- PB1-F2 and PA-X - other modulators of host responses -- Acknowledgments -- References -- PART 3: Evolution and ecology of influenza viruses -- 11: Ecology and evolution of influenza viruses in wild and domestic birds -- Introduction -- Recognition of the influenza ecosystem -- Aquatic birds as the natural reservoir of influenza A viruses -- Interspecies transmission of avian influenza viruses -- Natural reservoirs -- Recognition of influenza viruses in wild birds worldwide -- Wild birds: anseriformes -- Wild birds: charadriiformes -- Wild birds: other species -- Perpetuation, replication, and transmission in the wild bird populations -- Influenza in domestic birds -- Recognition of influenza viruses in domestic birds worldwide -- Interaction between wild and domestic birds -- Terrestrial poultry -- Prevalence and perpetuation in poultry -- Maintenance in domestic ducks and geese -- Establishment and development in terrestrial poultry -- Genesis and development of highly pathogenic H5 and H7 influenza viruses -- HPAI H5N1 virus -- H5N1 outbreaks in domestic birds -- H5N1 in wild birds -- H5N1 in mammals. 327 $aInterspecies transmission -- Interspecies transmission from aquatic birds to terrestrial poultry -- Interspecies transmission to humans and other mammals -- Evolution of influenza A virus in different hosts -- Evolution of influenza viruses in aquatic birds and the formation of Eurasian and American influenza gene pools -- Reassortment -- Evolution of influenza viruses in domestic birds -- Evolution of the HPAI H5N1 virus -- Conclusions and outlook -- References -- 12: Influenza in swine -- Influenza as a swine disease -- Molecular epidemiology of swine influenza viruses -- Molecular epidemiology in North America -- Molecular epidemiology in Europe -- Molecular epidemiology in South-East Asia -- Cross-species transmission of swine influenza viruses -- Swine as intermediate hosts -- Challenges to the control of swine influenza -- Challenges in swine influenza surveillance -- Knowledge gaps -- Acknowledgments -- References -- 13: Equine/Canine/Feline/Seal influenza -- Equine influenza -- History -- Pathology -- Virus characterization -- Vaccines -- Experimental challenge models -- Infectivity of EIV for humans -- Canine influenza -- Equine origin CIV (H3N8) -- Avian origin influenza A virus H3N2 -- Avian origin influenza A virus H5N1 -- A/H1N1pdm09 virus -- Other -- Feline influenza -- Influenza in marine mammals -- Acknowledgments -- References -- 14: Emergence and evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains -- Definition of pandemic influenza disease -- Background -- Determinants of evolution and emergence of pandemic influenza virus strains -- Evolution resulting from gene segment reassortment -- Evolution resulting from fixation of genomic mutations -- Emergence of novel virus strains -- Extinction of seasonal strains -- The 1918, 1957, 1968, and 2009 influenza virus pandemics -- The H1N1 "Spanish" influenza pandemic of 1918 -- The H2N2 "Asian" pandemic virus of 1957. 327 $apt. 1. Influenza : perspective -- pt. 2. Structure and replication -- pt. 3. Evolution and ecology of influenza viruses -- pt. 4. Epidemiology and surveillance -- pt. 5. Immunology of influenza -- pt. 6. Vaccines and vaccine development -- pt. 7. Clinical aspects and antivirals -- pt. 8. The outbreak of H7N9. 330 $aThe Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: Influenza Perspectives Structure and Replication Evolution and Ecology Epidemiology and Surveillance Immunology Vaccines and Vaccine Development Clinical Aspects and Antivirals Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners. 606 $aInfluenza 606 $aInfluenza viruses 606 $aInfluenza, Human$3(DNLM)D007251 615 0$aInfluenza. 615 0$aInfluenza viruses. 615 12$aInfluenza, Human. 676 $a616.2/03 701 $aWebster$b Robert G.$f1932-$01672374 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910814767203321 996 $aTextbook of influenza$94105082 997 $aUNINA