LEADER 04471nam 2200505 450 001 9910797445803321 005 20230725061058.0 010 $a3-11-043664-7 024 7 $a10.1515/9783110436648 035 $a(CKB)3710000000455829 035 $a(MiAaPQ)EBC5024745 035 $a(DE-B1597)456532 035 $a(OCoLC)979906580 035 $a(DE-B1597)9783110436648 035 $a(Au-PeEL)EBL5024745 035 $a(CaPaEBR)ebr11566017 035 $a(EXLCZ)993710000000455829 100 $a20180611h20112015 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aStructural and catalytic roles of metal ions in RNA /$fedited by Astrid Sigel, Helmut Sigel, Roland K. O. Sigel 210 1$aBerlin ;$aMunich ;$aBoston :$cDe Gruyter,$d2011. 210 4$d©2015 215 $a1 online resource (424 pages) $cillustrations 225 1 $aMetal ions in life sciences,$x1559-0836 ;$vVolume 9 311 $a3-11-044282-5 327 $tFrontmatter -- $tHistorical Development and Perspectives of the Series / $rSigel, Astrid / Sigel, Helmut / Sigel, Roland K. O. -- $tPreface to Volume 9: Structural and Catalytic Roles of Metal Ions in RNA -- $tContents -- $tContributors to Volume 9 -- $tTitles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- $tContents of Volumes in the Metal Ions in Life Sciences Series -- $t1 Metal Ion Binding to RNA / $rAuffinger, Pascal / Grover, Neena / Westhof, Eric -- $t2 Methods to Detect and Characterize Metal Ion Binding Sites in RNA / $rErat, Michèle C. / Sigel, Roland K. O. -- $t3 Importance of Diffuse Metal Ion Binding to RNA / $rTan, Zhi-Jie / Chen, Shi-Jie -- $t4 RNA Quadruplexes / $rHalder, Kangkan / Hartig, Jörg S. -- $t5 The Roles of Metal Ions in Regulation by Riboswitches / $rFerré-D'Amaré, Adrian R. / Winkler, Wade C. -- $t6 Metal Ions: Supporting Actors in the Playbook of Small Ribozymes / $rJohnson-Buck, Alexander E. / McDowell, Sarah E. / Walter, Nils G. -- $t7 Multiple Roles of Metal Ions in Large Ribozymes / $rDonghi, Daniela / Schnabl, Joachim -- $t8 The Spliceosome and Its Metal Ions / $rButcher, Samuel E. -- $t9 The Ribosome: A Molecular Machine Powered by RNA / $rTrappl, Krista / Polacek, Norbert -- $t10 Metal Ion Requirements in Artificial Ribozymes that Catalyze Aminoacylation and Redox Reactions / $rSuga, Hiroaki / Futai, Kazuki / Jin, Koichiro -- $t11 Metal Ion Binding and Function in Natural and Artificial Small RNA Enzymes from a Structural Perspective / $rWedekind, Joseph E. -- $t12 Binding of Kinetically Inert Metal Ions to RNA: The Case of Platinum(II) / $rChapman, Erich G. / Hostetter, Alethia A. / Osborn, Maire F. / Miller, Amanda L. / DeRose, Victoria J. -- $tSubject Index 330 $aThe discovery of ribozymes nearly 30 years ago triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in MILS 9. This book, written by 28 internationally recognized experts from 8 nations, provides a most up-to-date view and is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes in an authoritative and timely manner in 12 stimulating chapters, supported by nearly 1600 references, 13 tables, and 75 illustrations, mostly in color, metal ion-binding motifs, methods to detect and characterize metal ion-binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The spliceosome, the ribosome, ribozymes involving redox cofactors as well as the binding of kinetically inert metal ions to RNA are also covered. 410 0$aMetal ions in life sciences ;$vVolume 9. 606 $aCatalytic RNA 615 0$aCatalytic RNA. 676 $a572.88 702 $aSigel$b Astrid 702 $aSigel$b Helmut 702 $aSigel$b Roland K. O. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797445803321 996 $aStructural and catalytic roles of metal ions in RNA$93841468 997 $aUNINA