LEADER 04603nam 2200553 450 001 9910797425103321 005 20200520144314.0 010 $a0-12-802592-1 035 $a(CKB)3710000000462443 035 $a(EBL)2146996 035 $a(MiAaPQ)EBC2146996 035 $a(Au-PeEL)EBL2146996 035 $a(CaPaEBR)ebr11090798 035 $a(CaONFJC)MIL822677 035 $a(OCoLC)918841190 035 $a(PPN)198666071 035 $a(EXLCZ)993710000000462443 100 $a20150901d2015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aBone morphogenic protein /$fseries editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California 205 $aFirst edition. 210 1$aWaltham, MA :$cElsevier,$d2015. 215 $a1 online resource (367 p.) 225 1 $aVitamins and Hormones,$x0083-6729 ;$vvolume 99 300 $aDescription based upon print version of record. 311 $a0-12-802442-9 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor ? Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGF? Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGF? Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity 327 $a6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGF? Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 327 $a3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-?/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-?/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-?/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 327 $a4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-?/BMP Signaling; 4.3. Key Regulatory Steps in TGF-?/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 327 $a5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References 327 $aChapter Four: The Role of BMP Signaling and NF-?B Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... 410 0$aVitamins and hormones ;$vv. 99. 606 $aBone morphogenetic proteins 615 0$aBone morphogenetic proteins. 676 $a612.75 702 $aLitwack$b Gerald 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797425103321 996 $aBone morphogenic protein$93802666 997 $aUNINA