LEADER 05341nam 2200661 450 001 9910797252503321 005 20230120002230.0 010 $a0-12-802869-6 010 $a0-12-802827-0 035 $a(CKB)3710000000421222 035 $a(EBL)2067961 035 $a(SSID)ssj0001539537 035 $a(PQKBManifestationID)11823091 035 $a(PQKBTitleCode)TC0001539537 035 $a(PQKBWorkID)11531612 035 $a(PQKB)11163565 035 $a(MiAaPQ)EBC2067961 035 $a(Au-PeEL)EBL2067961 035 $a(CaPaEBR)ebr11064148 035 $a(CaONFJC)MIL798027 035 $a(OCoLC)910964263 035 $a(EXLCZ)993710000000421222 100 $a20150620h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPeptide and protein vaccines /$fedited by Rossen Donev 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (192 p.) 225 1 $aAdvances in Protein Chemistry and Structural Biology,$x1876-1623 ;$vVolume 99 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $aFront Cover; Peptide and Protein Vaccines; Copyright; Contents; Contributors; Preface; References; Chapter 1: Peptide Immunotherapy in Vaccine Development: From Epitope to Adjuvant; 1. Introduction; 2. Cancer Vaccine; 3. Allergy Vaccine; 4. Alzheimers? Disease Vaccine; 5. Adjuvant and Delivery; 6. Perspectives and Conclusions; References; Chapter 2: The Use of Liposomes to Shape Epitope Structure and Modulate Immunogenic Responses of Peptide Vaccines Against...; 1. Introduction; 2. MPER: ASite of Vulnerability on HIV-1 Env and a Linear Epitope; 3. Structural Organization of MPER 327 $a3.1. Hydrophobicity Distribution3.2. MPER Peptide Structure; 4. Lipid Vesicles: Adjuvants and Devices to Shape MPER Structure; 4.1. Liposomes as Adjuvants; 4.2. The Lipid Bilayer as an MPER Scaffold; 5. Immunogenicity Studies of MPER-Derived Peptides in Liposomes; References; Chapter 3: Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant; 1. Introduction; 2. Establishment of High Expression Recombinant Lipoprotein System; 3. The Lipid Structure of Lipoprotein; 4. Recombinant Lipoprotein with Intrinsic Adjuvant Properties 327 $a5. To Engineer Chimeric Lipoproteins with Intrinsic Adjuvant for Novel Vaccine Development6. Recombinant Chimeric Lipoproteins Can Activate BMDCs; 7. A Robustness Up- and Downstream Processes for Lipoprotein Production; 8. Recombinant Lipoprotein-Based Subunit Vaccine Induces High Titers of Neutralizing Antibody and Longer Memory Immune Re...; 9. Recombinant Lipidated Human Papillomavirus E7 Induces Cellular Immune Responses and Protective Immunity Against Cervic...; 10. Conclusion; Acknowledgment; References 327 $aChapter 4: Perspective of Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers1. Introduction; 2. Licensed Adjuvants; 3. CpG-DNA: Adjuvant; 4. Phosphodiester Bond CpG-DNA; 5. Liposomes: Adjuvants; 6. Adjuvants for Peptide Vaccine; 7. Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.1. Antibody Production with Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.2. Prevention of Influenza A Virus Infection; 7.3. Prevention of Respiratory Syncytial Virus Infection 327 $a7.4. Cancer Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers8. Perspectives; Acknowledgments; References; Chapter 5: Chemical Platforms for Peptide Vaccine Constructs; 1. Introduction; 2. Multiple Antigenic Peptide System Using a PolyLys Core: ABoon to Synthetic Peptide Vaccines; 3. Synthetic Antigen Carrier Bearing N-(S-acetylmercaptoacetyl)-Glutamyl Residues; 4. Thioester as a Replacement for Natural Peptide Bond (Chemical Ligation): Construction of Proteins; 5. Synthetic Peptide Dendrimer with Thiazolidinyl Pendant 327 $a6. Oxime Chemistry for Synthetic Peptide-Based Vaccines 330 $aPublished continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in a wide bioscience areaChapters are written by authorities in their fieldTargeted to a wide audience of researchers, specialists, and studentsThe information provided in the volume is well s 410 0$aAdvances in protein chemistry and structural biology ;$vVolume 99. 606 $aPeptides$xTherapeutic use 606 $aProteins$xTherapeutic use 606 $aPeptide drugs 615 0$aPeptides$xTherapeutic use. 615 0$aProteins$xTherapeutic use. 615 0$aPeptide drugs. 676 $a572.65 702 $aDonev$b Rossen 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797252503321 996 $aPeptide and protein vaccines$93857367 997 $aUNINA