LEADER 04471nam 2200613 450 001 9910797053903321 005 20230807214056.0 010 $a1-119-20945-5 010 $a1-118-94730-4 035 $a(CKB)3710000000375289 035 $a(EBL)1895374 035 $a(SSID)ssj0001493227 035 $a(PQKBManifestationID)11815856 035 $a(PQKBTitleCode)TC0001493227 035 $a(PQKBWorkID)11527463 035 $a(PQKB)10506365 035 $a(MiAaPQ)EBC1895374 035 $a(Au-PeEL)EBL1895374 035 $a(CaPaEBR)ebr11033610 035 $a(CaONFJC)MIL770066 035 $a(OCoLC)904978937 035 $a(EXLCZ)993710000000375289 100 $a20150330h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe 4 lenses of innovation $ea power tool for creative thinking /$fRowan Gibson ; design by Adriana Matallana 210 1$aHoboken, New Jersey :$cWiley,$d2015. 210 4$dİ2015 215 $a1 online resource (303 p.) 300 $aIncludes index. 311 $a1-118-74024-6 327 $aCover; Title Page; Copyright; Contents; Preface; Acknowledgments; Introduction; Part One: The Mind of the Innovator; The Elusive Source of Creative Genius; Challenging Orthodoxies; Harnessing Trends; Leveraging Resources; Understanding Needs; The Four Lenses of Innovation; Time for an Innovation Renaissance; Lessons to Take Away; Part Two: The Power of Patterns; Seeing Things from a Fresh Perspective; What's wrong with Our Brains?; The Pattern-Recognition Principle; Why We Stop Noticing; The Pattern of the Crowd; Resistance to Change; Patterns and Innovation; Sharpening Our Perceptive Powers 327 $aA Power Tool for Creative ThinkingLessons to Take Away; Part Three: Looking Through the Four Lenses; "Here's to the Crazy Ones"; What Exactly Is an Orthodoxy?; Meet the Challengers; On a Path of Disruption; Innovation Means Shifting Assumptions; Ready to Rethink Everything?; Lessons to Take Away; Seeing the Future in the Present; A Global "Change Bomb"; The Race for Tomorrow; Learning to Ride the Waves; Meet the Trend Surfers; The Man from the Future; Fast-Forward Companies; It's Happening Now!; The Next Big Thing for Your Business; Lessons to Take Away; Repurpose, Redeploy, & Recombine 327 $aHow would You Define Google?Leveraging Resources in New Ways; Extending the Boundaries of the Business; Stretching into New Spaces; Unlimited Potential for Growth; Exploiting Underutilized Assets; What Else Could We Do with This?; Leveraging Resources from Others; Lessons to Take Away; Innovating from the Customer Backward; Do Customers Really Know What They Want?; What's Wrong with It?; Understanding Particular Customer Groups; Innovating for Local Needs and Tastes; Matching What Is Possible with What Is Needed; Lessons to Take Away; Part Four: How Big Ideas are Built 327 $aThe Archimedes PrincipleRethinking the Universe; 8 Steps to Building a Breakthrough; Inventing the 20th Century; Unpacking the Creative Process; "Say Good Bye to the Bag"; Different Routes to Big Ideas; Lessons to Take Away; What Exactly Is an Insight?; Do Insights Come from Breakthrough Thinking? Or Does Breakthrough Thinking Come from Insights?; A Practical Definition of Insights; Understanding Ideation; Stepping Stones for Creative Thinking; Improving Your Capacity for Radical Innovation; How Powerful Are Your Insights?; Working with the Four Lenses; Lessons to Take Away; Notes 327 $aImage CreditsIndex; About the Author; EULA 330 $a ROWAN GIBSON is widely recognized around the globe as a thought leader on business innovation. Labeled by the media as ""the Innovation Grandmaster,"" Gibson provides some of the world's most successful organizations with services and tools to help them deepen their innovation capabilities. He is also the cofounder of InnovationExcellence.com, which is now the most popular innovation website on the Internet. 606 $aOrganizational change 606 $aCreative ability in business 615 0$aOrganizational change. 615 0$aCreative ability in business. 676 $a658.4063 700 $aGibson$b Rowan$0127340 702 $aMatallana$b Adriana 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797053903321 996 $aThe 4 lenses of innovation$93793055 997 $aUNINA LEADER 04092nam 22006855 450 001 9910253931703321 005 20200629143259.0 010 $a3-319-46877-4 024 7 $a10.1007/978-3-319-46877-8 035 $a(CKB)3710000001151963 035 $a(DE-He213)978-3-319-46877-8 035 $a(MiAaPQ)EBC4838235 035 $a(PPN)200512757 035 $a(EXLCZ)993710000001151963 100 $a20170407d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNext Generation Antibody Drug Conjugates (ADCs) and Immunotoxins /$fedited by Ulf Grawunder, Stefan Barth 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XI, 181 p. 57 illus., 39 illus. in color.) 225 1 $aMilestones in Drug Therapy,$x2296-6056 311 $a3-319-46875-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aChemical Assembly of Antibody-Drug Conjugates -- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers -- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents -- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications -- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates -- Substance P ? Saporin for the Treatment of Intractable Pain -- Recombinant immunotoxins for Chronic Inflammatory Disease -- BL22: A milestone in targeting CD22. 330 $aThis book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. 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