LEADER 04876nam 2200649 450 001 9910797044003321 005 20230120002220.0 010 $a0-12-803008-9 010 $a0-12-803028-3 035 $a(CKB)3710000000377224 035 $a(EBL)2000912 035 $a(SSID)ssj0001493950 035 $a(PQKBManifestationID)11807439 035 $a(PQKBTitleCode)TC0001493950 035 $a(PQKBWorkID)11515055 035 $a(PQKB)11110470 035 $a(MiAaPQ)EBC2000912 035 $a(Au-PeEL)EBL2000912 035 $a(CaPaEBR)ebr11036391 035 $a(CaONFJC)MIL759355 035 $a(OCoLC)906137374 035 $a(MiAaPQ)EBC201885 035 $a(EXLCZ)993710000000377224 100 $a20150411h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHormones and transport systems /$fedited by Gerald Litwack ; contributors, Yasaman Aghazadeh [and thirty-eight others] 205 $aFirst edition. 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (584 p.) 225 1 $aVitamins and Hormones,$x0083-6729 ;$vVolume ninety eight 300 $aDescription based upon print version of record. 311 $a1-336-28069-7 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Hormones and Transport Systems; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Dietary I- Absorption: Expression and Regulation of the Na+/I- Symporter in the Intestine; 1. The Importance of Iodide in Human Health; 2. The Na+/I- Symporter; 2.1. Molecular identification of NIS; 2.2. NIS-mediated transport: Substrates and stoichiometry; 2.3. The role of physiological Na+ concentrations in NIS affinity for I-; 3. NIS Expression Beyond the Thyroid; 4. Targeting of NIS to the Plasma Membrane; 5. Hormonal Regulation of NIS Expression; 6. Dietary I- Absorption 327 $a7. Regulation of Intestinal NIS Expression8. Conclusions and Future Directions; Acknowledgments; References; Chapter Two: Apical Iodide Efflux in Thyroid; 1. Introduction; 2. Iodide and Thyroid Hormone Synthesis; 2.1. Thyroid organization; 2.2. Thyroid hormone synthesis; 3. Vectorial Transport Processes in Epithelia and Thyroid I- Accumulation; 3.1. Brief overview of basic epithelial transport processes; 3.2. Basolateral iodide uptake; 3.3. Apical iodide release; 4. Chloride Transport Proteins and Luminal I- Translocation; 4.1. SLC26A4 (Pendrin); 4.1.1. SLC26A4, HCO3-, luminal pH 327 $a4.2. Cystic fibrosis transmembrane conductance regulator4.2.1. CFTR and SLC26A4 interplay; 4.3. SLC5A8, a sodium-monocarboxylate transporter (hAIT; SLC5A8; SMCT1); 4.4. TMEM16A (anoctamin 1); 5. Conclusions; Acknowledgment; References; Chapter Three: The Sodium/Multivitamin Transporter: A Multipotent System with Therapeutic Implications; 1. Introduction; 2. ""Active"" Transport; 3. Identification of the Multivitamin Transporter; 4. The hSMVT Gene; 4.1. Expression of hSMVT in various tissues; 4.2. An additional high-affinity hSMVT-like uptake system?; 5. From Gene to Protein; 6. Family Ties 327 $a7. The Predicted Structure of hSMVT8. The (Co)Substrates of hSMVT; 9. The Characterization of the Cloned hSMVT; 9.1. Electrogenicity of hSMVT-mediated transport; 9.2. Mechanistic implications; 10. Medical Implications; 11. Conclusion and Future Directions; Acknowledgments; References; Chapter Four: Regulation of ?ENaC Transcription; 1. Introduction; 1.1. Aldosterone is a ligand for the mineralocorticoid receptor and glucocorticoid receptor; 1.2. Epithelial sodium channel (ENaC) is a major target of aldosterone action and a key ion channel in regulating Na+ balance 327 $a2. Dot1a-Af9 Complex Mediates Repression of ?ENaC2.1. Histone H3 K79 methyltransferase Dot1a; 2.1.1. Dot1 proteins are a unique class of histone methyltransferases; 2.1.2. Dot1 proteins and H3 K79 methylation have diverse functions; 2.1.3. Dot1a is the first aldosterone-regulated target with a known function in epigenetics; 2.1.4. Dot1a modulates targeted H3 K79 methylation at the ?ENaC promoter and represses ?ENaC in a methyltransferase-depen...; 2.1.5. Dot1a-mediated repression apparently requires its nuclear expression as well as its methyltransferase activity and... 327 $a2.1.6. Dot1a-mediated repression of ?ENaC raised new questions 410 0$aVitamins and hormones ;$vVolume ninety eight. 606 $aHormones 615 0$aHormones. 676 $a612.4 702 $aLitwack$b Gerald 702 $aAghazadeh$b Yasaman 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910797044003321 996 $aHormones and transport systems$93739392 997 $aUNINA