LEADER 03415nam 2200493 450 001 9910795347603321 005 20230630001418.0 010 $a9783736965256$b(electronic bk.) 010 $z9783736975255 035 $a(MiAaPQ)EBC6807926 035 $a(Au-PeEL)EBL6807926 035 $a(CKB)19909371600041 035 $a(OCoLC)1286428703 035 $a(EXLCZ)9919909371600041 100 $a20220814d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHemisynthesis of phenolic metabolites /$fSarah Straßmann 205 $a1st ed. 210 1$aGo?ttingen :$cCuvillier Verlag,$d[2021] 210 4$d©2021 215 $a1 online resource (123 pages) 225 0 $aSchriftenreihe der Professur fu?r Molekulare Lebensmitteltechnologie ;$vBand 10 311 08$aPrint version: Straßmann, Sarah Hemisynthesis of phenolic metabolites Göttingen : Cuvillier Verlag,c2021 9783736975255 320 $aIncludes bibliographical references. 327 $aIntro -- Preliminary remarks -- List of abbreviations -- List of publications -- Conferences -- Declaration of contribution as co-author -- Chapter 1 General Introduction -- 1 Polyphenols -- 2 Anthocyanins -- 2.3 Physiological properties -- 3 Synthesis of phase II metabolites -- 3.1 Enzymatic synthesis -- 3.2 Chemical synthesis -- 3.3 Microbial synthesis -- 4 Analysis and Characterization of the metabolites -- 4.1 UV/Vis spectra -- 4.2 Mass spectrometry -- 4.3 Purification -- 5 Aims of the thesis -- Chapter 2 Hemisynthesis of Anthocyanin Phase II Metabolites byPorcine Liver Enzymes -- 1 Introduction -- 2 Materials and methods -- 2.1 Chemicals -- 2.2 Isolation of anthocyanins -- 2.3 Preparation of liver fractions -- 2.4 Incubation -- 3 Results and discussion -- 3.1 Methylation -- 3.2 Glucuronidation -- 3.3 Sulfation -- 3.4 Multiple Conversions -- 4 References -- Chapter 3 Chemical Hemisynthesis of Sulfated Cyanidin-3-OGlucosideand Cyanidin Metabolites -- 1 Introduction -- 2 Results and discussion -- 2.1 Cyanidin Sulfates -- 2.2 Cyanidin-3-O-Glucoside Sulfates -- 2.3 Challenges -- 2.4 Human Pilot Study -- 3 Materials and methods -- 3.1 Chemicals -- 3.2 Hemisynthesis of Sulfated Metabolites -- 3.3 LC-MS-Analysis -- 3.4 Study Design and Analysis of Urine -- 4 Conclusions -- 5 References -- Chapter 4 Methylation of Cyanidin-3-O-Glucoside with DimethylCarbonat e -- 1 Introduction -- 2 Results and discussion -- 2.1 First Observations -- 2.2 Experimental Design -- 2.3 Increase in Solvation of Anthocyanins -- 2.4 Identification -- 3 Materials and methods -- 3.1 Chemicals -- 3.2 Hemisynthesis -- 3.3 LC-MS Analysis -- 4 Conclusion -- 5 References -- Chapter 5 Concluding remarks -- 1 Impact of contributions -- 2 Remaining challenges and future directions -- 3 References -- Summary -- Zusammenfassung -- Acknowledgement. 410 0$aSchriftenreihe der Professur für Molekulare Lebensmitteltechnologie 606 $aPolyphenols 606 $aMetabolites 606 $aAnthocyanins 615 0$aPolyphenols. 615 0$aMetabolites. 615 0$aAnthocyanins. 676 $a572.2 700 $aStraßmann$b Sarah$01549599 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910795347603321 996 $aHemisynthesis of phenolic metabolites$93807774 997 $aUNINA