LEADER 02904nam 2200421 450 001 9910794679403321 005 20231110231159.0 010 $a1-77170-053-X 035 $a(CKB)4100000011813244 035 $a(MiAaPQ)EBC6605866 035 $a(Au-PeEL)EBL6605866 035 $a(OCoLC)1250081018 035 $a(EXLCZ)994100000011813244 100 $a20220528h20202014 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aOur human variability $ea conversation with Stephen Scherer /$fedited with an introduction by Howard Burton 210 1$a[Place of publication not identified] :$cIdeas Roadshow,$d[2020] 210 4$d©2014 215 $a1 online resource (78 pages) 225 1 $aIdeas Roadshow Conversations 327 $aIntro -- A Note on the Text -- Introduction -- The Conversation -- I. James Watson's Legacy -- II. In the Lab -- III. Chromosome 7 -- IV. Back to Basics -- V. Revolutionary Stirrings -- VI. Going Global -- VII. Variability and Evolution -- VIII. Causes and Implications -- IX: Towards Treatment -- X. The Definition of Disease -- XI. Probing Deeper -- XII. Ethical and Societal Issues -- XIII. Future Possibilities -- XIV. Contact with Autism -- XV. Nobel Thoughts -- XVI. The Human Condition -- Continuing the Conversation. 330 $aThis book is based on an in-depth filmed conversation between Howard Burton and Stephen Scherer, the GlaxoSmithKline Research Chair in Genome Sciences at the Hospital for Sick Children and University of Toronto. Stephen Scherer discusses his lifelong passion for science that culminated in his groundbreaking discovery of copy-number variation. This wide-ranging conversation also covers his exciting work in autism research and how copy number variation brings us a deeper understanding of both human variability and disease.This carefully-edited book includes an introduction, More Things in DNA, Horatio..., and questions for discussion at the end of each chapter. Howard Burton was the Founding Director of Canada's Perimeter Institute for Theoretical Physics. He holds a PhD in theoretical physics and an MA in philosophy. This book is part of an expanding series of 100+ Ideas Roadshow conversations, each one presenting a wealth of candid insights from a leading expert in a focused yet informal setting to provide a uniquely accessible window into frontline research and scholarship that wouldn't otherwise be encountered through standard lectures and textbooks. 410 0$aIdeas Roadshow Conversations 606 $aVariation (Biology) 615 0$aVariation (Biology) 676 $a576.54 702 $aBurton$b Howard 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910794679403321 996 $aOur human variability$93764765 997 $aUNINA LEADER 06947nam 22007935 450 001 9910734833403321 005 20260311160407.0 010 $a3-031-31570-7 024 7 $a10.1007/978-3-031-31570-1 035 $a(CKB)27588190300041 035 $a(DE-He213)978-3-031-31570-1 035 $a(MiAaPQ)EBC30645966 035 $a(Au-PeEL)EBL30645966 035 $a(PPN)272256382 035 $a(EXLCZ)9927588190300041 100 $a20230713d2023 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAlzheimer?s Disease Research $eWhat Has Guided Research So Far and Why It Is High Time for a Paradigm Shift /$fby Christian Behl 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (XXV, 652 p. 116 illus., 107 illus. in color.) 311 08$a9783031315695 327 $aChapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer?s Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer?s Research Goes Deeper ? Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer?s Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer?s Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer?s Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer?s Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer?s Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer?s Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change". 330 $aThis book highlights the key phases and central findings of Alzheimer?s Disease research since the introduction of the label ?Alzheimer?s Disease? in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer?s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer?s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer?s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. Withits extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer?s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer?s research community is finally ready to shed its ?amyloid-straitjacket? that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer?s Disease research and provide a new and broader perspective on this age-dependent brain disease. 606 $aNeurosciences 606 $aNeurology 606 $aNervous system$xDiseases 606 $aCognitive neuroscience 606 $aNeurophysiology 606 $aLearning$xPhysiological aspects 606 $aMemory$xPhysiological aspects 606 $aNeuroscience 606 $aNeurology 606 $aNeurological Disorders 606 $aCognitive Neuroscience 606 $aNeurophysiology 606 $aLearning and Memory 606 $aMalaltia d'Alzheimer$2thub 606 $aInvestigació mèdica$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 0$aNeurology. 615 0$aNervous system$xDiseases. 615 0$aCognitive neuroscience. 615 0$aNeurophysiology. 615 0$aLearning$xPhysiological aspects. 615 0$aMemory$xPhysiological aspects. 615 14$aNeuroscience. 615 24$aNeurology. 615 24$aNeurological Disorders. 615 24$aCognitive Neuroscience. 615 24$aNeurophysiology. 615 24$aLearning and Memory. 615 7$aMalaltia d'Alzheimer 615 7$aInvestigació mèdica 676 $a612.8 676 $a616.83110072 700 $aBehl$b Christian$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058337 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910734833403321 996 $aAlzheimer?s Disease Research$93566439 997 $aUNINA