LEADER 02618nam 2200421 450 001 9910794549303321 005 20230629215217.0 010 $a3-7369-6409-9 035 $a(CKB)4100000011964030 035 $a(MiAaPQ)EBC6645824 035 $a(Au-PeEL)EBL6645824 035 $a(OCoLC)1257667258 035 $a(EXLCZ)994100000011964030 100 $a20220206d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDetection of pathogenic infections in neurological disorders through recycling of gene expression data /$fAnna-Maria Liebhoff 205 $a1. Auflage. 210 1$aGo?ttingen :$cCuvillier Verlag,$d[2021] 210 4$dİ2021 215 $a1 online resource (143 pages) 311 $a3-7369-7409-4 320 $aIncludes bibliographical references. 327 $aIntro -- 1 Introduction -- 2 Biological background -- 2.1 Ribonucleic acid (RNA) -- 2.2 Small RNA -- 2.3 Sequencing -- 2.4 Microbiology -- 2.5 Neurodegenerative diseases -- 2.6 Pathogens in neurological diseases -- 3 Bioinformatics background -- 3.1 Data sources -- 3.2 Metadata and biological ontologies -- 3.3 Read alignment -- 3.4 Comparative analysis -- 3.5 Metagenomic analysis -- 3.6 Integrated analysis pipelines -- 4 Computer science background -- 4.1 Web development -- 4.2 Data science and machine learning -- 5 Small RNA Expression Atlas (SEA) -- 5.1 Background -- 5.2 System architecture -- 5.3 Implementation -- 5.4 System behavior -- 5.5 Results -- 6 Biological discoveries through SEA -- 6.1 Tissue specificity of small RNA -- 6.2 User data and Parkinson's disease -- 6.3 Pathogens in neurodegenerative diseases -- 6.4 Sex specificity of small RNA in human body -- 6.5 Discussion -- 7 Pathogen detection in RNA-seq data -- 7.1 Background -- 7.2 Identification algorithm -- 7.3 Performance measures -- 7.4 Evaluation -- 8 Path(ogen)s to disease -- 8.1 Analysis pipeline -- 8.2 Burkholderia stabilis in frontotemporal dementia -- 8.3 Discussion -- 9 Conclusion -- Bibliography -- A SEA JSON communication objects -- B Pathonoia algorithms -- C Detailed analysis results. 606 $aRNA viruses$xResearch$xMethodology 615 0$aRNA viruses$xResearch$xMethodology. 676 $a579.25 700 $aLiebhoff$b Anna-Maria$01582513 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910794549303321 996 $aDetection of pathogenic infections in neurological disorders through recycling of gene expression data$93864977 997 $aUNINA