LEADER 01549nam 2200445I 450 001 9910711660703321 005 20181207122236.0 035 $a(CKB)5470000002485454 035 $a(OCoLC)1078406189 035 $a(EXLCZ)995470000002485454 100 $a20181207j201811 ua 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPhysical and biological properties of cobalt-and copper-doped calcium phosphates as bone substitute materials /$fHaley V. Cummings 210 1$aMoffett Field, CA :$cNational Aeronautics and Space Administration, Ames Research Center,$dNovember 2018. 215 $a1 online resource (vi, 65 pages) $cillustrations (some color) 225 1 $aNASA/TM ;$v2018-220015 300 $a"November 2018." 320 $aIncludes bibliographical references (pages 53-65). 606 $aBones$2nasat 606 $aBiological effects$2nasat 606 $aCobalt$2nasat 606 $aDoped crystals$2nasat 606 $aMechanical properties$2nasat 615 7$aBones. 615 7$aBiological effects. 615 7$aCobalt. 615 7$aDoped crystals. 615 7$aMechanical properties. 700 $aCummings$b Haley V.$01418017 712 02$aAmes Research Center, 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910711660703321 996 $aPhysical and biological properties of cobalt-and copper-doped calcium phosphates as bone substitute materials$93528173 997 $aUNINA LEADER 02855oam 2200469 450 001 9910794404303321 005 20230523102333.0 010 $a0-7453-4351-1 010 $a0-7453-4353-8 035 $a(CKB)4100000011778623 035 $a(MiAaPQ)EBC6498828 035 $a(EXLCZ)994100000011778623 100 $a20210817d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAugmented exploitation $eartificial intelligence, automation and work /$feditors, Phoebe Moore, Jamie Woodcock 210 1$aLondon :$cPluto Press,$d[2021] 210 4$d©2021 215 $a1 online resource (193 pages) $cillustrations 300 $aIncludes index. 311 1 $a0-7453-4349-X 327 $aAI trainers: who is the smart worker today? / Phoebe V. Moore -- Work now, profit later: AI between capital, labour, and regulation / Toni Prug and Pas?ko Bilic? -- Delivering food on bikes: between machinic subordination and autonomy in the algorithmic workplace / Benjamin Herr -- Putting the habitus to work: digital presumption, surveillance, and distinction / Eduard Mu?ller -- The power of prediction: people analytics at work / Uwe Vormbusch and Peter Kels -- Manufacturing consent in the gig economy / Luca Perrig -- Automated and autonomous?: technologies mediating the exertion and perception of labour control / Beatriz Casas ?Gonza?lez -- Can robots produce customer confidence?: contradictions among automation, new mechanisms of control, and resistances in the banking labour process / Giorgio Boccardo -- It gets better with age: AI and the labour process in old and new gig-economy firms / Adam Badger -- Self-tracking and sousveillance at work: insights from human-computer interaction and social science / Marta E. Cecchinato, Sandy J. J. Gould, and Frederick Harry Pitts -- Breaking digital atomisation: resistant cultures of solidarity in platform-based courier work / Heiner Heiland and Simon Schaupp -- Resisting the algorithmic boss: guessing, gaming, reframing, and contesting rules in app-based management / Joanna Bronowicka and Mirela Ivanova. 330 $aArtificial intelligence should be changing society, not reinforcing capitalist notions of work. 606 $aManagement information systems 606 $aDecision making$xData processing 606 $aArtificial intelligence 615 0$aManagement information systems. 615 0$aDecision making$xData processing. 615 0$aArtificial intelligence. 676 $a658.4030028563 702 $aWoodcock$b Jamie$4edt 702 $aMoore$b Phoebe V.$4edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910794404303321 996 $aAugmented exploitation$93684979 997 $aUNINA LEADER 04718nam 2200649 450 001 9910829994603321 005 20230725024900.0 010 $a1-282-77490-5 010 $a9786612774904 010 $a3-527-64162-9 010 $a3-527-63094-5 010 $a3-527-63095-3 035 $a(CKB)2670000000043896 035 $a(EBL)584982 035 $a(SSID)ssj0000412224 035 $a(PQKBManifestationID)11294106 035 $a(PQKBTitleCode)TC0000412224 035 $a(PQKBWorkID)10366516 035 $a(PQKB)10109589 035 $a(MiAaPQ)EBC584982 035 $a(MiAaPQ)EBC4042285 035 $a(OCoLC)714797092 035 $a(EXLCZ)992670000000043896 100 $a20160331h20102010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAspartic acid proteases as therapeutic targets /$fedited by Arun K. Ghosh 210 1$aWeinheim, Germany :$cWiley-VCH,$d2010. 210 4$d©2010 215 $a1 online resource (641 p.) 225 1 $aMethods and Principles in Medicinal Chemistry ;$vVolume 45 300 $aDescription based upon print version of record. 311 $a3-527-31811-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aAspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design 327 $a6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 327 $a11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 327 $a15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index 330 $aIn this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal 410 0$aMethods and principles in medicinal chemistry ;$vVolume 45. 606 $aAspartic proteinases 606 $aAspartic proteinases$xInhibitors$xTherapeutic use 615 0$aAspartic proteinases. 615 0$aAspartic proteinases$xInhibitors$xTherapeutic use. 676 $a571.9/36 676 $a612.01516 702 $aGhosh$b Arun K.$cProf. Dr., 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829994603321 996 $aAspartic acid proteases as therapeutic targets$94078874 997 $aUNINA